| Tag | Content |
|---|
| CPLM ID | CPLM-012584 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription elongation factor A protein 2 |
Protein Synonyms/Alias | Testis-specific S-II; Transcription elongation factor S-II protein 2; Transcription elongation factor TFIIS.l |
Gene Name | TCEA2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 58 | MSVNALRKQSSDEEV | ubiquitination | [1] |
|
Reference | [1] Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. Tan F, Lu L, Cai Y, Wang J, Xie Y, Wang L, Gong Y, Xu BE, Wu J, Luo Y, Qiang B, Yuan J, Sun X, Peng X. Proteomics. 2008 Jul;8(14):2885-96. [ PMID: 18655026] |
Functional Description | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
Sequence Annotation | DOMAIN 6 83 TFIIS N-terminal.
DOMAIN 138 254 TFIIS central.
ZN_FING 257 297 TFIIS-type.
CROSSLNK 58 58 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 299 AA |
Protein Sequence | MMGKEEEIAR IARRLDKMVT KKSAEGAMDL LRELKAMPIT LHLLQSTRVG MSVNALRKQS 60
SDEEVIALAK SLIKSWKKLL DASDAKARER GRGMPLPTSS RDASEAPDPS RKRPELPRAP 120
STPRITTFPP VPVTCDAVRN KCREMLTAAL QTDHDHVAIG ADCERLSAQI EECIFRDVGN 180
TDMKYKNRVR SRISNLKDAK NPDLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK 240
EAIREHQMAR TGGTQTDLFT CGKCRKKNCT YTQVQTRSSD EPMTTFVVCN ECGNRWKFC 299 |
Gene Ontology | GO:0005813; C:centrosome; IDA:HPA. GO:0008023; C:transcription elongation factor complex; NAS:UniProtKB. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006354; P:DNA-dependent transcription, elongation; NAS:UniProtKB. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0032784; P:regulation of DNA-dependent transcription, elongation; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |