UniProt Accession

 NRBP_HUMAN; Q9UHY1; B3KV40; D6W558; Q53FZ5; Q96SU3 

Genbank Protein ID

 AF113249; AK001946; AK027538; AK122664; AL136682; AK223136; AC074117; CH471053; CH471053; CH471053; BC001221 

Genbank Nucleotide ID

 AAF21967.1; BAA91993.1; BAB55185.1; BAG53652.1; CAB66617.1; BAD96856.1; AAY14847.1; EAX00578.1; EAX00579.1; EAX00580.1; AAH01221.1 

Protein Name

 Nuclear receptor-binding protein 

Protein Synonyms/Alias

  

Gene Name

 NRBP1 

Gene Synonyms/Alias

 BCON3; NRBP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
134	LNIVKFHKYWADIKE	acetylation	[1]
231	DTINNHVKTCREEQK	ubiquitination	[2]
306	LQREFIQKCLQSEPA	ubiquitination	[2]
517	LLEETLNKFNFARNS	ubiquitination	[2, 3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. 

Sequence Annotation

 DOMAIN 68 327 Protein kinase.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 433 433 Phosphothreonine.
 MOD_RES 441 441 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Cell projection; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 535 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0012505; C:endomembrane system; IDA:UniProtKB.
 GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IDA:UniProtKB.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS50011; PROTEIN_KINASE_DOM 

PRINTS