UniProt Accession

 C1GLC_HUMAN; Q96EU7; A8K246; Q8WWS3; Q9NZX1 

Genbank Protein ID

 AB084170; AY159319; AJ238398; AF161552; AF177284; AY358642; AC011890; AK290111; CH471107; BC011930; BC050441 

Genbank Nucleotide ID

 BAC41493.1; AAN78129.1; CAC80277.1; AAF29039.1; AAQ13670.1; AAQ89005.1; BAF82800.1; EAX11873.1; AAH11930.1; AAH50441.1 

Protein Name

 C1GALT1-specific chaperone 1 

Protein Synonyms/Alias

 C38H2-like protein 1; C38H2-L1; Core 1 beta1,3-galactosyltransferase 2; C1Gal-T2; C1GalT2; Core 1 beta3-Gal-T2; Core 1 beta3-galactosyltransferase-specific molecular chaperone 

Gene Name

 C1GALT1C1 

Gene Synonyms/Alias

 COSMC; HSPC067; MSTP143; UNQ273/PRO310 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
206	SLLNIPEKCPEQGGM	ubiquitination	[1]
243	NAEDADGKDVFNTKS	ubiquitination	[1, 2]
249	GKDVFNTKSVGLSIK	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). 

Sequence Annotation

  

Keyword

 Chaperone; Complete proteome; Disease mutation; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; TAS:Reactome.
 GO:0016266; P:O-glycan processing; TAS:Reactome.
 GO:0043687; P:post-translational protein modification; TAS:Reactome. 

Interpro

 IPR026731; C1GALT1C1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS