UniProt Accession

 FKBP3_YEAST; P38911; D6W0K9 

Genbank Protein ID

 L34569; X79379; S73876; Z46373; AY693136; BK006946 

Genbank Nucleotide ID

 AAB04165.1; CAA55924.1; AAB31995.1; CAA86504.1; AAT93155.1; DAA09823.1 

Protein Name

 FK506-binding nuclear protein 

Protein Synonyms/Alias

 FKBP-70; Nucleolar proline isomerase; Peptidyl-prolyl cis-trans isomerase; PPIase; Proline rotamase 

Gene Name

 FPR3 

Gene Synonyms/Alias

 NPI46; YML074C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
48	EAIDEENKPSTLRII	acetylation	[1]
48	EAIDEENKPSTLRII	ubiquitination	[2]
343	KNGKVFDKNTSGKPF	acetylation	[1]
348	FDKNTSGKPFAFKLG	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 PPIases accelerate the folding of proteins. FK506- and rapamycin-binding protein. Specifically binds nuclear localization sequences. May be involved in the assembly or folding of ribosomal proteins. 

Sequence Annotation

 DOMAIN 324 411 PPIase FKBP-type.
 MOTIF 256 271 Nuclear localization signal (Potential).
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 81 81 Phosphoserine.
 MOD_RES 89 89 Phosphothreonine.
 MOD_RES 184 184 Phosphotyrosine; by CK2.
 MOD_RES 186 186 Phosphoserine; by CK2.  

Keyword

 Complete proteome; Isomerase; Nucleus; Phosphoprotein; Reference proteome; Rotamase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 411 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IDA:SGD.
 GO:0000412; P:histone peptidyl-prolyl isomerization; IBA:RefGenome.
 GO:0051598; P:meiotic recombination checkpoint; IMP:SGD.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW. 

Interpro

 IPR026257; FK506_BP.
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 

Pfam

 PF00254; FKBP_C 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE 

PRINTS