CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019302
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 4-hydroxybenzoate polyprenyltransferase, mitochondrial 
Protein Synonyms/Alias
 COQ2 homolog; hCOQ2; Para-hydroxybenzoate--polyprenyltransferase; PHB:polyprenyltransferase 
Gene Name
 COQ2 
Gene Synonyms/Alias
 CL640 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
265DDVLIGLKSTALRFGubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Isoprene biosynthesis; Membrane; Mitochondrion; Reference proteome; Transferase; Transit peptide; Transmembrane; Transmembrane helix; Ubiquinone biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 371 AA 
Protein Sequence
MLGSRAAGFA RGLRALALAW LPGWRGRSFA LARAAGAPHG GDLQPPACPE PRGRQLSLSA 60
AAVVDSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA AEPGCFPDWY MLSLFGTGAI 120
LMRGAGCTIN DMWDQDYDKK VTRTANRPIA AGDISTFQSF VFLGGQLTLA LGVLLCLNYY 180
SIALGAGSLL LVITYPLMKR ISYWPQLALG LTFNWGALLG WSAIKGSCDP SVCLPLYFSG 240
VMWTLIYDTI YAHQDKRDDV LIGLKSTALR FGENTKPWLS GFSVAMLGAL SLVGVNSGQT 300
APYYAALGAV GAHLTHQIYT LDIHRPEDCW NKFISNRTLG LIVFLGIVLG NLWKEKKTDK 360
TKKGIENKIE N 371 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IEA:EC.
 GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:EC.
 GO:0006071; P:glycerol metabolic process; IGI:UniProtKB.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
 GO:0006744; P:ubiquinone biosynthetic process; IDA:UniProtKB. 
Interpro
 IPR006370; HB_polyprenyl-transferase.
 IPR000537; UbiA_prenyltransferase. 
Pfam
 PF01040; UbiA 
SMART
  
PROSITE
 PS00943; UBIA 
PRINTS