UniProt Accession

 KCNA3_HUMAN; P22001; Q5VWN2 

Genbank Protein ID

 L23499; AL365361; CH471122; BC035059; M55515; M85217; M38217 

Genbank Nucleotide ID

 AAC31761.1; CAH71983.1; EAW56457.1; AAH35059.2; AAA36425.1; AAA59457.1; AAB88073.1 

Protein Name

 Potassium voltage-gated channel subfamily A member 3 

Protein Synonyms/Alias

 HGK5; HLK3; HPCN3; Voltage-gated K(+) channel HuKIII; Voltage-gated potassium channel subunit Kv1.3 

Gene Name

 KCNA3 

Gene Synonyms/Alias

 HGK5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
120	LRFETQLKTLCQFPE	ubiquitination	[1]
134	ETLLGDPKRRMRYFD	ubiquitination	[1, 2]
196	LGEEAMEKFREDEGF	ubiquitination	[1]
526	RSNSTLSKSEYMVIE	ubiquitination	[1, 2]
569	PNSCVNIKKIFTDV*	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. 

Sequence Annotation

 MOTIF 444 449 Selectivity filter (By similarity).
 MOTIF 573 575 PDZ-binding (By similarity).
 MOD_RES 520 520 Phosphoserine; by PKA (Potential).
 LIPID 317 317 S-palmitoyl cysteine (Potential).
 CARBOHYD 279 279 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Complete proteome; Glycoprotein; Ion channel; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 575 AA 

Protein Sequence

Gene Ontology

 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0008076; C:voltage-gated potassium channel complex; TAS:ProtInc.
 GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome.
 GO:0015271; F:outward rectifier potassium channel activity; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:InterPro.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR003091; K_chnl.
 IPR003968; K_chnl_volt-dep_Kv.
 IPR003972; K_chnl_volt-dep_Kv1.
 IPR004050; K_chnl_volt-dep_Kv1.3.
 IPR003131; T1-type_BTB. 

Pfam

 PF00520; Ion_trans
 PF02214; K_tetra 

SMART

 SM00225; BTB 

PROSITE

  

PRINTS

 PR00169; KCHANNEL.
 PR01510; KV13CHANNEL.
 PR01491; KVCHANNEL.
 PR01496; SHAKERCHANEL.