UniProt Accession

 COF2_MOUSE; P45591 

Genbank Protein ID

 L29468; BC007138 

Genbank Nucleotide ID

 AAA37433.1; AAH07138.1 

Protein Name

 Cofilin-2 

Protein Synonyms/Alias

 Cofilin, muscle isoform 

Gene Name

 Cfl2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
34	EEIKKRKKAVLFCLS	acetylation	[1]
44	LFCLSDDKRQIIVEE	acetylation	[1]
44	LFCLSDDKRQIIVEE	ubiquitination	[2]
92	YDATYETKESKKEDL	ubiquitination	[3]
112	APESAPLKSKMIYAS	ubiquitination	[2]
144	VNGLDDIKDRSTLGE	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144] 

Functional Description

 Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. 

Sequence Annotation

 DOMAIN 4 153 ADF-H.
 MOTIF 30 34 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 3 3 Phosphoserine.
 MOD_RES 6 6 Phosphothreonine.
 MOD_RES 89 89 Phosphotyrosine.  

Keyword

 Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 166 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0030042; P:actin filament depolymerization; IEA:InterPro. 

Interpro

 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR017904; ADF/Cofilin/Destrin.
 IPR027234; Cofilin_1/2. 

Pfam

 PF00241; Cofilin_ADF 

SMART

 SM00102; ADF 

PROSITE

 PS51263; ADF_H 

PRINTS

 PR00006; COFILIN.