CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018349
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Stonin-2 
Protein Synonyms/Alias
 Stoned B 
Gene Name
 STON2 
Gene Synonyms/Alias
 STN2; STNB 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
353SISSTTGKSQRDSLIubiquitination[1]
384SHSDAVEKLKQLQIDubiquitination[2]
684FRTVFAEKTLPFTLRubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Adapter protein involved in endocytic machinery. May be involved in the vesicle recycling. May facilitate clathrin-coated vesicle uncoating. 
Sequence Annotation
 DOMAIN 427 560 SHD.
 DOMAIN 568 878 MHD.
 MOTIF 313 315 NPF 1.
 MOTIF 329 331 NPF 2.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Endocytosis; Membrane; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 905 AA 
Protein Sequence
MTTLDHVIAT HQSEWVSFNE EPPFPAHSQG GTEEHLPGLS SSPDQSESSS GENHVVDGGS 60
QDHSHSEQDD SSEKMGLISE AASPPGSPEQ PPPDLASAIS NWVQFEDDTP WASTSPPHQE 120
TAETALPLTM PCWTCPSFDS LGRCPLTSES SWTTHSEDTS SPSFGCSYTD LQLINAEEQT 180
SGQASGADST DNSSSLQEDE EVEMEAISWQ ASSPAMNGHP APPVTSARFP SWVTFDDNEV 240
SCPLPPVTSP LKPNTPPSAS VIPDVPYNSM GSFKKRDRPK STLMNFSKVQ KLDISSLNRT 300
PSVTEASPWR ATNPFLNETL QDVQPSPINP FSAFFEEQER RSQNSSISST TGKSQRDSLI 360
VIYQDAISFD DSSKTQSHSD AVEKLKQLQI DDPDHFGSAT LPDDDPVAWI ELDAHPPGSA 420
RSQPRDGWPM MLRIPEKKNI MSSRHWGPIF VKLTDTGYLQ LYYEQGLEKP FREFKLEICH 480
EISEPRLQNY DENGRIHSLR IDRVTYKEKK KYQPKPAVAH TAEREQVIKL GTTNYDDFLS 540
FIHAVQDRLM DLPVLSMDLS TVGLNYLEEE ITVDVRDEFS GIVSKGDNQI LQHHVLTRIH 600
ILSFLSGLAE CRLGLNDILV KGNEIVLRQD IMPTTTTKWI KLHECRFHGC VDEDVFHNSR 660
VILFNPLDAC RFELMRFRTV FAEKTLPFTL RTATSVNGAE VEVQSWLRMS TGFSANRDPL 720
TQVPCENVMI RYPVPSEWVK NFRRESVLGE KSLKAKVNRG ASFGSTSVSG SEPVMRVTLG 780
TAKYEHAFNS IVWRINRLPD KNSASGHPHC FFCHLELGSD REVPSRFANH VNVEFSMPTT 840
SASKASVRSI SVEDKTDVRK WVNYSAHYSY QVALGSIWLM LPTPFVHPTT LPLLFLLAML 900
TMFAW 905 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0030100; P:regulation of endocytosis; ISS:UniProtKB. 
Interpro
 IPR008968; Clathrin_mu_C.
 IPR012320; SHD.
 IPR017110; Stonin.
 IPR022699; Stonin2_N. 
Pfam
 PF00928; Adap_comp_sub
 PF12016; Stonin2_N 
SMART
  
PROSITE
 PS51072; MHD
 PS51070; SHD 
PRINTS