| Tag | Content |
|---|
| CPLM ID | CPLM-024215 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Shootin-1 |
Protein Synonyms/Alias | |
Gene Name | KIAA1598 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 17 | LQLITSLKEQAIGEY | ubiquitination | [1] | | 406 | TEEVTDLKRQAVEEM | ubiquitination | [1] | | 466 | STSSRSLKSLDPENS | ubiquitination | [1] | | 485 | ERILRRRKVTAEADS | ubiquitination | [1] | | 524 | TKTALNKKTLEAEFN | ubiquitination | [1] | | 616 | GEIQPENKEDSIENV | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons (By similarity). |
Sequence Annotation | MOD_RES 3 3 Phosphoserine (By similarity).
MOD_RES 4 4 Phosphoserine (By similarity).
MOD_RES 249 249 Phosphoserine.
MOD_RES 464 464 Phosphoserine (By similarity).
MOD_RES 467 467 Phosphoserine (By similarity).
MOD_RES 496 496 Phosphothreonine.
MOD_RES 506 506 Phosphoserine.
MOD_RES 515 515 Phosphoserine.
MOD_RES 532 532 Phosphoserine.
MOD_RES 537 537 Phosphothreonine. |
Keyword | Alternative splicing; Cell projection; Coiled coil; Complete proteome; Developmental protein; Direct protein sequencing; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 631 AA |
Protein Sequence | MNSSDEEKQL QLITSLKEQA IGEYEDLRAE NQKTKEKCDK IRQERDEAVK KLEEFQKISH 60
MVIEEVNFMQ NHLEIEKTCR ESAEALATKL NKENKTLKRI SMLYMAKLGP DVITEEINID 120
DEDSTTDTDG AAETCVSVQC QKQIKELRDQ IVSVQEEKKI LAIELENLKS KLVEVIEEVN 180
KVKQEKTVLN SEVLEQRKVL EKCNRVSMLA VEEYEEMQVN LELEKDLRKK AESFAQEMFI 240
EQNKLKRQSH LLLQSSIPDQ QLLKALDENA KLTQQLEEER IQHQQKVKEL EEQLENETLH 300
KEIHNLKQQL ELLEEDKKEL ELKYQNSEEK ARNLKHSVDE LQKRVNQSEN SVPPPPPPPP 360
PLPPPPPNPI RSLMSMIRKR SHPSGSGAKK EKATQPETTE EVTDLKRQAV EEMMDRIKKG 420
VHLRPVNQTA RPKTKPESSK GCESAVDELK GILGTLNKST SSRSLKSLDP ENSETELERI 480
LRRRKVTAEA DSSSPTGILA TSESKSMPVL GSVSSVTKTA LNKKTLEAEF NSPSPPTPEP 540
GEGPRKLEGC TSSKVTFQPP SSIGCRKKYI DGEKQAEPVV VLDPVSTHEP QTKDQVAEKD 600
PTQHKEDEGE IQPENKEDSI ENVRETDSSN C 631 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |