UniProt Accession

 SCRIB_MOUSE; Q80U72; Q6P5H7; Q7TPH8; Q80VB1; Q8CI48; Q8VII1; Q922S3 

Genbank Protein ID

 AF441233; AK122211; BC006859; BC037480; BC049942; BC062888; AF271735 

Genbank Nucleotide ID

 AAL32469.1; BAC65493.1; AAH06859.1; AAH37480.1; AAH49942.1; AAH62888.1; AAP88019.1 

Protein Name

 Protein scribble homolog 

Protein Synonyms/Alias

 Scribble; Protein LAP4 

Gene Name

 Scrib 

Gene Synonyms/Alias

 Kiaa0147; Lap4; Scrib1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
53	NQLRELPKPFFRLLN	ubiquitination	[1]
105	PESIKFCKALEIADF	ubiquitination	[1]
164	ELRENLLKSLPASLS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. 

Sequence Annotation

 REPEAT 37 58 LRR 1.
 REPEAT 60 81 LRR 2.
 REPEAT 83 104 LRR 3.
 REPEAT 106 127 LRR 4.
 REPEAT 129 150 LRR 5.
 REPEAT 152 174 LRR 6.
 REPEAT 175 197 LRR 7.
 REPEAT 198 219 LRR 8.
 REPEAT 221 243 LRR 9.
 REPEAT 244 265 LRR 10.
 REPEAT 267 288 LRR 11.
 REPEAT 290 312 LRR 12.
 REPEAT 313 334 LRR 13.
 REPEAT 336 357 LRR 14.
 REPEAT 359 381 LRR 15.
 REPEAT 382 402 LRR 16.
 DOMAIN 714 801 PDZ 1.
 DOMAIN 848 936 PDZ 2.
 DOMAIN 990 1079 PDZ 3.
 DOMAIN 1086 1180 PDZ 4.
 REGION 1 804 Sufficient for targeting to adherens
 REGION 703 1215 Interaction with ARHGEF7 (By similarity).
 MOD_RES 583 583 Phosphoserine.
 MOD_RES 674 674 Phosphothreonine.
 MOD_RES 675 675 Phosphothreonine.
 MOD_RES 812 812 Phosphothreonine (By similarity).
 MOD_RES 821 821 Phosphoserine (By similarity).
 MOD_RES 925 925 Phosphoserine (By similarity).
 MOD_RES 1126 1126 Phosphoserine (By similarity).
 MOD_RES 1206 1206 Phosphoserine.
 MOD_RES 1209 1209 Phosphoserine (By similarity).
 MOD_RES 1218 1218 Phosphoserine (By similarity).
 MOD_RES 1292 1292 Phosphoserine (By similarity).
 MOD_RES 1325 1325 Phosphothreonine (By similarity).
 MOD_RES 1331 1331 Phosphoserine (By similarity).
 MOD_RES 1361 1361 Phosphoserine.
 MOD_RES 1430 1430 Phosphoserine (By similarity).
 MOD_RES 1457 1457 Phosphoserine.
 MOD_RES 1468 1468 Phosphoserine (By similarity).
 MOD_RES 1529 1529 Phosphoserine (By similarity).
 MOD_RES 1548 1548 Phosphoserine.  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Leucine-rich repeat; Membrane; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1612 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0005913; C:cell-cell adherens junction; ISS:UniProtKB.
 GO:0035748; C:myelin sheath abaxonal region; IDA:BHF-UCL.
 GO:0045211; C:postsynaptic membrane; IEA:Compara.
 GO:0042734; C:presynaptic membrane; IEA:Compara.
 GO:0034750; C:Scrib-APC-beta-catenin complex; IEA:Compara.
 GO:0032863; P:activation of Rac GTPase activity; ISS:UniProtKB.
 GO:0060561; P:apoptotic process involved in morphogenesis; ISS:UniProtKB.
 GO:0008105; P:asymmetric protein localization; IMP:MGI.
 GO:0016477; P:cell migration; IMP:UniProtKB.
 GO:0008283; P:cell proliferation; ISS:UniProtKB.
 GO:0016337; P:cell-cell adhesion; ISS:UniProtKB.
 GO:0035089; P:establishment of apical/basal cell polarity; ISS:UniProtKB.
 GO:0060603; P:mammary gland duct morphogenesis; IMP:UniProtKB.
 GO:0045930; P:negative regulation of mitotic cell cycle; ISS:UniProtKB.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0050918; P:positive chemotaxis; IMP:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
 GO:0001921; P:positive regulation of receptor recycling; IEA:Compara.
 GO:0071896; P:protein localization to adherens junction; IEA:Compara.
 GO:0048488; P:synaptic vesicle endocytosis; IMP:UniProtKB.
 GO:0016080; P:synaptic vesicle targeting; IMP:UniProtKB.
 GO:0042060; P:wound healing; IGI:MGI. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR001478; PDZ. 

Pfam

 PF12799; LRR_4
 PF00595; PDZ 

SMART

 SM00369; LRR_TYP
 SM00228; PDZ 

PROSITE

 PS51450; LRR
 PS50106; PDZ 

PRINTS