UniProt Accession

 Q544X6_MOUSE; Q544X6 

Genbank Protein ID

 AC102106; AC102268; AK004718; AK018738; AK159652 

Genbank Nucleotide ID

 BAB23501.1; BAB31379.1; BAE35263.1 

Protein Name

 Ferrochelatase 

Protein Synonyms/Alias

  

Gene Name

 Fech 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
105	MTLPIQNKLAPFIAK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the ferrous insertion into protoporphyrin IX (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Heme biosynthesis; Iron; Lyase; Porphyrin biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 422 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; TAS:MGI.
 GO:0004325; F:ferrochelatase activity; IDA:MGI.
 GO:0020037; F:heme binding; IDA:MGI.
 GO:0005506; F:iron ion binding; IDA:MGI.
 GO:0030350; F:iron-responsive element binding; IDA:MGI.
 GO:0008203; P:cholesterol metabolic process; IMP:MGI.
 GO:0009589; P:detection of UV; IMP:MGI.
 GO:0030218; P:erythrocyte differentiation; IMP:MGI.
 GO:0006783; P:heme biosynthetic process; IDA:MGI.
 GO:0055072; P:iron ion homeostasis; IMP:MGI.
 GO:0046501; P:protoporphyrinogen IX metabolic process; IGI:MGI.
 GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme; IMP:MGI.
 GO:0046984; P:regulation of hemoglobin biosynthetic process; IGI:MGI.
 GO:0034379; P:very-low-density lipoprotein particle assembly; IMP:MGI. 

Interpro

 IPR001015; Ferrochelatase.
 IPR019772; Ferrochelatase_AS. 

Pfam

 PF00762; Ferrochelatase 

SMART

  

PROSITE

 PS00534; FERROCHELATASE 

PRINTS