UniProt Accession

 Q80X81_MOUSE; Q80X81 

Genbank Protein ID

 AL589878; BC049873; AK143884; AK149441 

Genbank Nucleotide ID

 AAH49873.1; BAE25582.1; BAE28878.1 

Protein Name

 Acetyl-Coenzyme A acetyltransferase 3 

Protein Synonyms/Alias

 Protein Acat3 

Gene Name

 Acat3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
39	EMGTTVIKEVLQRAK	ubiquitination	[1]
46	KEVLQRAKVAPEEVS	ubiquitination	[1]
124	GGMENMSKAPHLTHL	ubiquitination	[1]
180	VSREAQDKVAVLSQN	acetylation	[2]
180	VSREAQDKVAVLSQN	ubiquitination	[1]
194	NRAEHAQKAGHFDKE	ubiquitination	[1]
200	QKAGHFDKEIVPVLV	acetylation	[2]
200	QKAGHFDKEIVPVLV	ubiquitination	[1]
211	PVLVSSRKGLTEVKI	ubiquitination	[1]
217	RKGLTEVKIDEFPRH	ubiquitination	[1]
233	SNLEAMGKLKPYFLT	ubiquitination	[1]
235	LEAMGKLKPYFLTDG	acetylation	[3]
235	LEAMGKLKPYFLTDG	ubiquitination	[1]
265	AAAVVLMKKTEAERR	ubiquitination	[1]
275	EAERRMLKPLARIVS	ubiquitination	[1]
302	VGPIPAIKQAVAKAG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 397 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. 

Interpro

 IPR002155; Thiolase.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr.
 IPR020610; Thiolase_AS.
 IPR020617; Thiolase_C.
 IPR020613; Thiolase_CS.
 IPR020616; Thiolase_N. 

Pfam

 PF02803; Thiolase_C
 PF00108; Thiolase_N 

SMART

  

PROSITE

 PS00737; THIOLASE_2
 PS00099; THIOLASE_3 

PRINTS