CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030647
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lamin A 
Protein Synonyms/Alias
 Lamin A, isoform CRA_a 
Gene Name
 Lmna 
Gene Synonyms/Alias
 mCG_8830 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
32RITRLQEKEDLQELNubiquitination[1]
78SREVSGIKAAYEAELubiquitination[1]
97KTLDSVAKERARLQLubiquitination[1]
108RLQLELSKVREEFKEubiquitination[1]
114SKVREEFKELKARNTubiquitination[1]
135LAAQARLKDLEALLNubiquitination[1]
144LEALLNSKEAALSTAubiquitination[1]
155LSTALSEKRTLEGELubiquitination[1]
171DLRGQVAKLEAALGEubiquitination[1]
180EAALGEAKKQLQDEMubiquitination[1]
181AALGEAKKQLQDEMLubiquitination[1]
201ENRLQTLKEELDFQKubiquitination[1]
208KEELDFQKNIYSEELubiquitination[1]
219SEELRETKRRHETRLubiquitination[1]
233LVEIDNGKQREFESRubiquitination[1]
270LEKTYSAKLDNARQSubiquitination[1]
311AQLSQLQKQLAAKEAubiquitination[1]
319QLAAKEAKLRDLEDSubiquitination[1]
378MEIHAYRKLLEGEEEubiquitination[1]
450EEVDEEGKFVRLRNKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Intermediate filament. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 665 AA 
Protein Sequence
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR 60
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN 120
TKKEGDLLAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK 180
KQLQDEMLRR VDAENRLQTL KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR 240
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID 300
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ 360
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQSQ GGGSVTKKRK 420
LESSESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIR RQNGDDPLMT 480
YRFPPKFTLK AGQVVTIWAS GAGATHSPPT DLVWKAQNTW GCGSSLRTAL INSTGEEVAM 540
RKLVRSLTMV EDNEDDDEDG EELLHHHRGS HCSGSGDPAE YNLRSRTVLC GTCGQPADKA 600
AGGAGAQVGG SISSGSSASS VTVTRSFRSV GGSGGGSFGD NLVTRSYLLG NSSPRSQSSQ 660
NCSIM 665 
Gene Ontology
 GO:0005638; C:lamin filament; IDA:MGI.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0006998; P:nuclear envelope organization; IGI:MGI.
 GO:0090343; P:positive regulation of cell aging; IEA:Compara.
 GO:0035105; P:sterol regulatory element binding protein import into nucleus; IMP:MGI.
 GO:0055015; P:ventricular cardiac muscle cell development; IMP:MGI. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR001322; Lamin_tail_dom. 
Pfam
 PF00038; Filament
 PF00932; LTD 
SMART
  
PROSITE
 PS00226; IF 
PRINTS