CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Merlin 
Protein Synonyms/Alias
  
Gene Name
 Nf2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
294ERRLLQMKEEATMANubiquitination[1]
326QITEEEAKLLAQKAAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 521 AA 
Protein Sequence
XVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL QVKKQILDEK 60
VYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT PEMWEERITA 120
WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFTIRNKKGT ELLLGVDALG LHIYDPENRL 180
TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC IGNHDLFMRR 240
RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL LQMKEEATMA 300
NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE EEKRLMEQKV 360
LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT YPPMNPIPPP 420
LPPDIPSFDI IADSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN ELKTEIEALK 480
LKERETALDV LHSESSDRGG PSSKHNTIKK PQAQGRRPIC I 521 
Gene Ontology
 GO:0005912; C:adherens junction; IMP:MGI.
 GO:0032154; C:cleavage furrow; IDA:MGI.
 GO:0030864; C:cortical actin cytoskeleton; IDA:MGI.
 GO:0019898; C:extrinsic to membrane; IEA:InterPro.
 GO:0030175; C:filopodium; IDA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0001726; C:ruffle; IDA:MGI.
 GO:0045216; P:cell-cell junction organization; IMP:MGI.
 GO:0007398; P:ectoderm development; IMP:MGI.
 GO:0001707; P:mesoderm formation; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.
 GO:0006469; P:negative regulation of protein kinase activity; IDA:MGI.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR011174; ERM.
 IPR011259; ERM_C_dom.
 IPR000798; Ez/rad/moesin_like.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018980; FERM_PH-like_C.
 IPR008954; Moesin.
 IPR011993; PH_like_dom. 
Pfam
 PF00769; ERM
 PF09380; FERM_C
 PF00373; FERM_M 
SMART
 SM00295; B41 
PROSITE
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.