CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025526
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 Ddx5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
120GEKLVKKKWNLDELPubiquitination[1]
131DELPKFEKNFYQEHPubiquitination[1]
282CIYGGAPKGPQIRDLubiquitination[1]
359MWSATWPKEVRQLAEubiquitination[1]
415MEEIMSEKENKTIVFubiquitination[1]
512GRTARSTKTGTAYTFubiquitination[1]
545ANQAINPKLLQLVEDubiquitination[1]
598RGYSNLLKRDFGAKTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Helicase; Hydrolase; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 690 AA 
Protein Sequence
EEAVQTIKAA AGTQPAPHSF PSVLALAAPA LDTTGPSAGD APAEASPSPR PSLRDSSPQD 60
STFTGFRPHT ATIDAMSSYS SDRDRGRDRG FGAPRFGGSR TGPLSGKKFG NPGEKLVKKK 120
WNLDELPKFE KNFYQEHPDL ARRTAQEVDT YRRSKEITVR GHNCPKPVLN FYEANFPANV 180
MDVIARQNFT EPTAIQAQGW PVALSGLDMV GVAQTGSGKT LSYLLPAIVH INHQPFLERG 240
DGPICLVLAP TRELAQQVQQ VAAEYCRACR LKSTCIYGGA PKGPQIRDLE RGVEICIATP 300
GRLIDFLECG KTNLRRTTYL VLDEADRMLD MGFEPQIRKI VDQIRPDRQT LMWSATWPKE 360
VRQLAEDFLK DYIHINIGAL ELSANHNILQ IVDVCHDVEK DEKLIRLMEE IMSEKENKTI 420
VFVETKRRCD ELTRKMRRDG WPAMGIHGDK SQQERDWVLN EFKHGKAPIL IATDVASRGL 480
DVEDVKFVIN YDYPNSSEDY IHRIGRTARS TKTGTAYTFF TPNNIKQVSD LISVLREANQ 540
AINPKLLQLV EDRGSGRSRG RGGMKDDRRD RYSAGKRGGF NTFRDRENYD RGYSNLLKRD 600
FGAKTQNGVY SAANYTNGSF GSNFVSAGIQ TSFRTGNPTG TYQNGYDSTQ QYGSNVANMH 660
NGMNQQAYAY PATAAAAPMI GYPMPTGYSQ 690 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; IC:MGI.
 GO:0030529; C:ribonucleoprotein complex; ISO:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004004; F:ATP-dependent RNA helicase activity; IEA:Compara.
 GO:0036002; F:pre-mRNA binding; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0003712; F:transcription cofactor activity; IDA:MGI.
 GO:0007623; P:circadian rhythm; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Compara.
 GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Compara.
 GO:0060765; P:regulation of androgen receptor signaling pathway; IEA:Compara.
 GO:0045069; P:regulation of viral genome replication; IEA:Compara. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR012587; P68HR.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C
 PF08061; P68HR 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS