CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025381
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Amidophosphoribosyltransferase 
Protein Synonyms/Alias
 ATase; Glutamine phosphoribosylpyrophosphate amidotransferase 
Gene Name
 Ppat 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
60SDGSAVPKFRVHKGMubiquitination[1]
220PVSDVNDKEKKSSETubiquitination[1]
372RQLGVAKKFGVLSDNubiquitination[1]
403NTISPIIKLLKESGAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 ACT_SITE 12 12 For GATase activity (By similarity).
 METAL 280 280 Iron-sulfur (4Fe-4S) (By similarity).
 METAL 426 426 Iron-sulfur (4Fe-4S) (By similarity).
 METAL 503 503 Iron-sulfur (4Fe-4S) (By similarity).
 METAL 506 506 Iron-sulfur (4Fe-4S) (By similarity).  
Keyword
 Glycosyltransferase; Iron; Iron-sulfur; Magnesium; Metal-binding; Purine biosynthesis; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 558 AA 
Protein Sequence
MELEELGIRE ECGVFGCIAS GDWPTQLDVP HVITLGLVGL QHRGQESAGI VTSDGSAVPK 60
FRVHKGMGLV NHVFTEDNLK KLYDSNLGIG HTRYATTGKC ELENCQPFVV ETLHGKIAVA 120
HNGELVNAAR LRKKLLRQGI GLSTSSDSEM ITQLLAYTPP QEKDDAPDWV ARIKNLMKEA 180
PAAYSLVIMH RDFIYAVRDP YGNRPLCIGR LMPVSDVNDK EKKSSETEGW VVSSESCSFL 240
SIGARYCHEV KPGEIVEISR HGIRTLDIIP RSNGDPVAFC IFEYVYFARP DSMFEDQMVY 300
TVRYRCGQQL AIEAPVEADL VSTVPESATP AALGYATKCG LPYVEVLCKN RYVGRTFIQP 360
NMRLRQLGVA KKFGVLSDNF KGKRIVLIDD SIVRGNTISP IIKLLKESGA KEVHIRVASP 420
PIKYPCFMGI NIPTKEELIA NKPEFDCLAE YLGANSVVYL SVEGLVSSVQ QEIKFKKQKV 480
KKHDIAIQEN GNGLEYFEKT GHCTACLTGQ YPVELEWWLP GQMCCFQTVG SSRSGLHTVV 540
TQVVPSGYHM LMYVYFKL 558 
Gene Ontology
 GO:0004044; F:amidophosphoribosyltransferase activity; IEA:EC.
 GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0006543; P:glutamine catabolic process; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro. 
Interpro
 IPR005854; Amd_phspho_trans.
 IPR017932; GATase_2_dom.
 IPR000583; GATase_dom.
 IPR000836; PRibTrfase_dom. 
Pfam
 PF00310; GATase_2
 PF00156; Pribosyltran 
SMART
  
PROSITE
 PS51278; GATASE_TYPE_2 
PRINTS