UniProt Accession

 SGTA_RAT; O70593; Q548F5 

Genbank Protein ID

 AJ222724; AF368278; BC087642 

Genbank Nucleotide ID

 CAA10960.1; AAP29456.1; AAH87642.1 

Protein Name

 Small glutamine-rich tetratricopeptide repeat-containing protein alpha 

Protein Synonyms/Alias

 Alpha-SGT; Small glutamine-rich protein with tetratricopeptide repeats 1 

Gene Name

 Sgta 

Gene Synonyms/Alias

 Sgt; Sgt1; Stg 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
95	SAEAERLKTEGNEQM	acetylation	[1]
160	GIDPGYSKAYGRMGL	acetylation	[1]
160	GIDPGYSKAYGRMGL	ubiquitination	[2]
200	DTYKSNLKIAELKLR	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. 

Sequence Annotation

 REPEAT 91 124 TPR 1.
 REPEAT 125 158 TPR 2.
 REPEAT 159 192 TPR 3.
 MOD_RES 81 81 Phosphothreonine.
 MOD_RES 137 137 N6-acetyllysine (By similarity).
 MOD_RES 302 302 Phosphoserine (By similarity).
 MOD_RES 304 304 Phosphothreonine (By similarity).
 MOD_RES 306 306 Phosphoserine (By similarity).  

Keyword

 Acetylation; Chaperone; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 314 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara. 

Interpro

 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00515; TPR_1 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS