CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013907
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TOM1-like protein 2 
Protein Synonyms/Alias
 Target of Myb-like protein 2 
Gene Name
 Tom1l2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
101FIDSVLVKIISPKNNubiquitination[1]
106LVKIISPKNNPPTIVubiquitination[1]
145VHIYEELKRRGIEFPubiquitination[1]
236DIVRGNTKVMSEMLTubiquitination[1]
400NSLAEQRKTVTYEDPubiquitination[1]
447VWLRTDLKGDDLEEGubiquitination[1]
462VTSEEFDKFLEERAKubiquitination[1]
469KFLEERAKAAETVPDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Probable role in protein transport. May regulate growth factor-induced mitogenic signaling (By similarity). 
Sequence Annotation
 DOMAIN 20 152 VHS.
 DOMAIN 219 307 GAT.
 MOTIF 329 334 Clathrin-binding.
 MOD_RES 160 160 Phosphoserine (By similarity).
 MOD_RES 164 164 Phosphothreonine (By similarity).
 MOD_RES 479 479 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA IRALKKRLSG 60
NRNYREVMLA LTVLETCVKN CGHRFHLLVA NRDFIDSVLV KIISPKNNPP TIVQDKVLAL 120
IQAWADAFRS SPDLTGVVHI YEELKRRGIE FPMADLDALS PIHTPQRSVP EMDPAATIPR 180
SQTQPRTTAG TYSSPPPASY STLQAPALSV TGPITANSEQ IARLRSELDI VRGNTKVMSE 240
MLTEMVPGQE DSSDLELLQE LNRTCRAMQH RIVELISRVS NEEVTEELLH VNDDLNNVFL 300
RYERFERYRS GRSVQNASNG VLSEVTEDNL IDLGPGSPAV VSPMVGSTAP PSSLSSQLAG 360
LDLGTESVSG TLSSLQQCKP QDGFDMFAQT RGNSLAEQRK TVTYEDPQAV GGLASALDNR 420
KQNSEMIPVA QPSVMDDIEV WLRTDLKGDD LEEGVTSEEF DKFLEERAKA AETVPDLPSP 480
PTEAPAPASN TSTRKKPERS DDALFAL 507 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR008942; ENTH_VHS.
 IPR004152; GAT.
 IPR014645; TOM1.
 IPR027429; TOM1L2.
 IPR002014; VHS.
 IPR018205; VHS_subgr. 
Pfam
 PF03127; GAT
 PF00790; VHS 
SMART
 SM00288; VHS 
PROSITE
 PS50909; GAT
 PS50179; VHS 
PRINTS