CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009056
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 2C37 
Protein Synonyms/Alias
 CYPIIC37 
Gene Name
 Cyp2c37 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
28RQSSERGKLPPGPTPubiquitination[1]
72YTLYLGRKPTVVLHGubiquitination[1]
84LHGYEAVKEALVDHGubiquitination[1]
105GRFPVFDKATNGMGLubiquitination[1]
116GMGLAFSKGNVWKNTubiquitination[1]
121FSKGNVWKNTRRFSLubiquitination[1]
190FQDRFDYKDRDFLNLubiquitination[1]
200DFLNLMEKLNEITKIacetylation[2, 3, 4]
200DFLNLMEKLNEITKIubiquitination[1]
235GSHKQFFKNYASIKNubiquitination[1]
241FKNYASIKNFLLEKIubiquitination[1]
247IKNFLLEKIKEHEESubiquitination[1]
249NFLLEKIKEHEESLDubiquitination[1]
322KYPHVTAKVQEEIEHubiquitination[1]
333EIEHVIGKHRSPCMQubiquitination[1]
375HEVTSDIKFRNYFIPubiquitination[1]
383FRNYFIPKGTTVITSubiquitination[1]
406TEFPNPEKFDPGHFLacetylation[4]
406TEFPNPEKFDPGHFLubiquitination[1]
418HFLDENGKFKKSDYFubiquitination[1]
420LDENGKFKKSDYFIPubiquitination[1]
421DENGKFKKSDYFIPFubiquitination[1]
432FIPFSTGKRICAGEGacetylation[4]
432FIPFSTGKRICAGEGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 Metabolizes arachidonic acid to produce 12- hydroxyeicosatetraenoic acid (HETE). 
Sequence Annotation
 METAL 435 435 Iron (heme axial ligand) (By similarity).  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 490 AA 
Protein Sequence
MDPILVLVLT LSCLFLLSLW RQSSERGKLP PGPTPLPIIG NILQIDVKDI CQSFTNLSKV 60
YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GEEFAGRGRF PVFDKATNGM GLAFSKGNVW 120
KNTRRFSLMT LRNLGMGKRS IEDRVQEEAR CLVEELRKTN GSPCDPTFIL GCAPCNVICS 180
IIFQDRFDYK DRDFLNLMEK LNEITKILSS PWLQICNTYP ALLDYCPGSH KQFFKNYASI 240
KNFLLEKIKE HEESLDVTIP RDFIDYFLIN GGQEDGNQPL QNRLEHLAIT VTDLFSAGTE 300
TTSTTLRYAI LLLLKYPHVT AKVQEEIEHV IGKHRSPCMQ DRSRMPYTDA MIHEVQRFID 360
LIPNSLPHEV TSDIKFRNYF IPKGTTVITS LSSVLHDSTE FPNPEKFDPG HFLDENGKFK 420
KSDYFIPFST GKRICAGEGL ARMELFLFLT SILQNFNLKP LVHPKDIDVT PMLIGLASVP 480
PAFQLCFIPS 490 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.