CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027454
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Helicase 45 
Protein Synonyms/Alias
  
Gene Name
 H45 
Gene Synonyms/Alias
 PF14_0655 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
109ELAQQIQKVVLALGDacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 398 AA 
Protein Sequence
MSTKEETFNN ENDIEGNTEE IVDTFDALGL NEKLLRGIYS YGFEKPSAIQ QRGIKPILNG 60
YDTIGQAQSG TGKTATFVIS SLQLINYDYV ACQALILAPT RELAQQIQKV VLALGDYLKV 120
KCHACVGGTV VREDIDKLKQ GVHMVVGTPG RVYDMIDKRH LGVDRLKLFI LDEADEMLSR 180
GFKAQIYEVF KKLVPDIQVA LFSATMPQEI LELTTRFMRD PKTILVKKDE LTLEGIRQFY 240
VAVEKEEWKL DTLCDLYETL TITQSIIYCN TRKKVDILTQ EMHNRLFTVS CMHGDMDQKD 300
RDLIMREFRS GSTRVLVTTD LLARGIDVQQ VSLVINYDLP ASPDTYIHRI GRSGRFGRKG 360
VAINFVTNDD KEKDKLKKIE SYYSTQIEEM PLEVADYL 398 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006446; P:regulation of translational initiation; ISS:GeneDB_Pfalciparum. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS