CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014784
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CWF19-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 CWF19L1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MAQKPLRLLACubiquitination[1]
62EYKTGIKKAPIQTYVubiquitination[1]
159LLTSPWPKCVGNFGNubiquitination[1]
174SSGEVDTKKCGSALVacetylation[2]
174SSGEVDTKKCGSALVubiquitination[1]
175SGEVDTKKCGSALVSubiquitination[1]
189SSLATGLKPRYHFAAubiquitination[1]
199YHFAALEKTYYERLPubiquitination[1]
297FFFDLNEKQGRKRSSubiquitination[3]
320PHPKQPRKPPQPPGPubiquitination[1]
483KLFHRIKKNFPLQFGubiquitination[2, 4, 5, 6]
505AILNVPDKSDWRQCQubiquitination[1, 7]
527TLARRFRKDFEPYDFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 538 AA 
Protein Sequence
MAQKPLRLLA CGDVEGKFDI LFNRVQAIQK KSGNFDLLLC VGNFFGSTQD AEWEEYKTGI 60
KKAPIQTYVL GANNQETVKY FQDADGCELA ENITYLGRKG IFTGSSGLQI VYLSGTESLN 120
EPVPGYSFSP KDVSSLRMML CTTSQFKGVD ILLTSPWPKC VGNFGNSSGE VDTKKCGSAL 180
VSSLATGLKP RYHFAALEKT YYERLPYRNH IILQENAQHA TRFIALANVG NPEKKKYLYA 240
FSIVPMKLMD AAELVKQPPD VTENPYRKSG QEASIGKQIL APVEESACQF FFDLNEKQGR 300
KRSSTGRDSK SSPHPKQPRK PPQPPGPCWF CLASPEVEKH LVVNIGTHCY LALAKGGLSD 360
DHVLILPIGH YQSVVELSAE VVEEVEKYKA TLRRFFKSRG KWCVVFERNY KSHHLQLQVI 420
PVPISCSTTD DIKDAFITQA QEQQIELLEI PEHSDIKQIA QPGAAYFYVE LDTGEKLFHR 480
IKKNFPLQFG REVLASEAIL NVPDKSDWRQ CQISKEDEET LARRFRKDFE PYDFTLDD 538 
Gene Ontology
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR006768; Cwf19-like_C_dom-1.
 IPR006767; Cwf19-like_C_dom-2.
 IPR011146; HIT-like. 
Pfam
 PF04677; CwfJ_C_1
 PF04676; CwfJ_C_2 
SMART
  
PROSITE
  
PRINTS