CPLM-020800

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-020800

UniProt Accession

TTYH1_MOUSE; Q9D3A9; Q6L751; Q6P0A7; Q8BRL4; Q8C7M4; Q9D5D1; Q9EQN7; Q9ESC3

Genbank Protein ID

AF190991; AF190699; DQ104403; AB162929; AK015486; AK018148; AK043998; AK048413; AK049903; BC046310; BC065694

Genbank Nucleotide ID

AAG15842.1; AAG02615.1; AAZ06803.1; BAD20188.1; BAB29865.1; BAB31094.1; BAC31730.1; BAC33329.1; BAC33980.1; AAH46310.1; AAH65694.1

Protein Name

Protein tweety homolog 1

Protein Synonyms/Alias

mTTY1

Gene Name

Ttyh1

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
441	PFNPQESKRLYQNRD	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Probable chloride channel. Isoform 3 may be a Ca(2+)- independent and swelling-activated chloride channel, possibly involved in regulation of cell volume. May be involved in cell adhesion (By similarity).

Sequence Annotation

MOD_RES 448 448 Phosphoserine.
MOD_RES 449 449 Phosphoserine.
CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
CARBOHYD 284 284 N-linked (GlcNAc...) (Potential).
CARBOHYD 355 355 N-linked (GlcNAc...) (Potential).

Keyword

Alternative splicing; Cell adhesion; Cell membrane; Chloride; Chloride channel; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

450 AA

Protein Sequence

MGAPPGYRPS AWVHLLHQLP RADFQLRPVP SGFAPRDQEY QQALLLVAAL AGLGLGLSLI 60
FIAVYLIRFC CCRPPEPHGA KSPPPGGGCV TWSCIAALLV GCAGIGIGFY GNSETSDGVS 120
QLSSALLHAN HTLSTIDDVV LETVERLGEA VKTELTTLEE VLSVRMELVA ATRGARRQAE 180
AAAQYLQGLA FWQGVSLSPV QVAEDVTFVE EYRWLAYVLL LLLVLLVCLF TLLGLAKQSK 240
WLVVVMTAMS LLVLVLSWGS MGLEAATAVG LSDFCSNPDT YVLNLTQEET GLSSDILSYY 300
FLCNQAVSNP FQQRLTLSQR ALASIHSQLQ GLEREAIPQF SAAQKPLLSL EETLNVTERS 360
FHQLVALLHC RSLHKDYGSA LRGLCEDALE GLLFLMLFSL LSAGALATTL CSLPRAWALF 420
PPSDDYDDTD DDDPFNPQES KRLYQNRDRS LRRESRIFAC SATRVI 466

Gene Ontology

GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
GO:0031527; C:filopodium membrane; IDA:MGI.
GO:0032433; C:filopodium tip; IDA:MGI.
GO:0030868; C:smooth endoplasmic reticulum membrane; IDA:MGI.
GO:0005509; F:calcium ion binding; IDA:MGI.
GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
GO:0016337; P:cell-cell adhesion; IDA:MGI.
GO:0031589; P:cell-substrate adhesion; IDA:MGI.
GO:0046847; P:filopodium assembly; IDA:MGI.
GO:0007067; P:mitosis; IMP:MGI.

Interpro

IPR006990; Tweety.

Pfam

PF04906; Tweety

SMART

PROSITE

PRINTS