CPLM-016378

Genbank Nucleotide ID

Thioredoxin-interacting protein

Protein Synonyms/Alias

Vitamin D3 up-regulated protein 1

Mus musculus (Mouse)

Position	Peptide	Type	References
19	VVFNDPEKVYGSGEK	ubiquitination	[1]
26	KVYGSGEKVAGRVIV	ubiquitination	[1]
64	MQGSQQCKQTLDYLR	ubiquitination	[1]
116	GPLGTSFKGKYGCVD	ubiquitination	[1]
118	LGTSFKGKYGCVDYW	ubiquitination	[1]
141	SQPTQEAKKNFEVMD	ubiquitination	[1]
164	LMAPVSAKKEKKVSC	ubiquitination	[1]
168	VSAKKEKKVSCMFIP	ubiquitination	[1]
188	VSARIDRKGFCEGDD	ubiquitination	[1]
213	CSRIVVPKAAIVARH	ubiquitination	[1]
229	YLANGQTKVFTQKLS	ubiquitination	[1]
234	QTKVFTQKLSSVRGN	ubiquitination	[1]
288	VSVPGSKKVILDLPL	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.

MOD_RES 362 362 Phosphoserine (By similarity).
CROSSLNK 213 213 Glycyl lysine isopeptide (Lys-Gly)

Alternative splicing; Cell cycle; Complete proteome; Cytoplasm; Isopeptide bond; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0005758; C:mitochondrial intermembrane space; IEA:Compara.
GO:0005634; C:nucleus; IEA:Compara.
GO:0004857; F:enzyme inhibitor activity; IDA:MGI.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0071228; P:cellular response to tumor cell; ISS:UniProtKB.
GO:0030216; P:keratinocyte differentiation; IEA:Compara.
GO:0051782; P:negative regulation of cell division; ISS:UniProtKB.
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:MGI.
GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
GO:0006606; P:protein import into nucleus; IMP:MGI.
GO:0042127; P:regulation of cell proliferation; IEA:Compara.
GO:0051592; P:response to calcium ion; IEA:Compara.
GO:0042493; P:response to drug; IEA:Compara.
GO:0032355; P:response to estradiol stimulus; IEA:Compara.
GO:0009749; P:response to glucose stimulus; IEA:Compara.
GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
GO:0009612; P:response to mechanical stimulus; IEA:Compara.
GO:0006979; P:response to oxidative stress; IDA:MGI.
GO:0032570; P:response to progesterone stimulus; IEA:Compara.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

IPR011021; Arrestin-like_N.
IPR011022; Arrestin_C-like.
IPR014756; Ig_E-set.

PF02752; Arrestin_C
PF00339; Arrestin_N