CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017199
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translational activator of cytochrome c oxidase 1 
Protein Synonyms/Alias
 Coiled-coil domain-containing protein 44; Translational activator of mitochondrially-encoded cytochrome c oxidase 1 
Gene Name
 Taco1 
Gene Synonyms/Alias
 Ccdc44 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
124STIESALKTEKNKGIacetylation[1]
127ESALKTEKNKGIYLLacetylation[2]
162PKCHLDIKYILNKNGacetylation[1, 2, 3]
182GARHFFDKKGVVVVGacetylation[3]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1 (By similarity). 
Sequence Annotation
  
Keyword
 Activator; Coiled coil; Complete proteome; Mitochondrion; Reference proteome; Translation regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 294 AA 
Protein Sequence
MMSWAAASLR MTAVPCFRVR CLGFRVGPWG ASQHANPGCG AAPHRTLHVS ATASAGHNKW 60
SKVRHIKGPK DMERSRIFSK LTLSIRLAVK EGGPNPENNS SLANILELCR SKNMPKSTIE 120
SALKTEKNKG IYLLYEGRGP GGSSLLIEAL SNSGPKCHLD IKYILNKNGG MMAEGARHFF 180
DKKGVVVVGV EDREKKAVNL ERALELAIEA GAEDVKEAED EEEKNLFKFI CDASSLHQVR 240
KKLDSLGLCP VSCSMEFIPH SKVQLAEPEL EQAAHLIQAL NNYEDVIHVY DNIE 294 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. 
Interpro
 IPR017856; Integrase_Zn-bd_dom-like_N.
 IPR002876; Transcrip_reg_TACO1-like.
 IPR026563; Transcrip_reg_TACO1-like_dom2.
 IPR026564; Transcrip_reg_TACO1-like_dom3. 
Pfam
 PF01709; Transcrip_reg 
SMART
  
PROSITE
  
PRINTS