UniProt Accession

 COR1C_HUMAN; Q9ULV4; B3KU12; Q9NSK5 

Genbank Protein ID

 AB030656; AK096363; AL162070; CH471054; BC002342 

Genbank Nucleotide ID

 BAA83077.1; BAG53274.1; CAB82406.1; EAW97826.1; AAH02342.1 

Protein Name

 Coronin-1C 

Protein Synonyms/Alias

 Coronin-3; hCRNN4 

Gene Name

 CORO1C 

Gene Synonyms/Alias

 CRNN4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
337	CEIARFFKLHERKCE	acetylation	[1]
391	DPILISLKHGYIPGK	ubiquitination	[2]
413	KKNILDSKPTANKKC	acetylation	[3]
440	ASVQNEAKLDEILKE	acetylation	[3]
446	AKLDEILKEIKSIKD	acetylation	[1]
471	KLEQQMAKIAA****	ubiquitination	[4]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May be involved in cytokinesis, motility, and signal transduction (By similarity). 

Sequence Annotation

 REPEAT 78 118 WD 1.
 REPEAT 128 168 WD 2.
 REPEAT 172 211 WD 3.
 REPEAT 263 303 WD 4.
 MOD_RES 301 301 Phosphotyrosine (By similarity).
 MOD_RES 446 446 N6-acetyllysine.  

Keyword

 Acetylation; Actin-binding; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 474 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IBA:RefGenome.
 GO:0051015; F:actin filament binding; IBA:RefGenome.
 GO:0030036; P:actin cytoskeleton organization; IBA:RefGenome.
 GO:0006909; P:phagocytosis; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR027333; CORO1C.
 IPR015505; Coronin.
 IPR015048; DUF1899.
 IPR015049; DUF1900.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF08953; DUF1899
 PF08954; DUF1900
 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS