UniProt Accession

 NDUA6_HUMAN; P56556; B2RE54; O43675; Q6FGW0; Q6IBT8; Q6IC39 

Genbank Protein ID

 CR456529; AL021878; CH471095; AK291874; AK316562; AF047182; CR456714; CR541997; BC002772 

Genbank Nucleotide ID

 CAG30415.1; EAW60489.1; BAF84563.1; BAG38151.1; AAC04267.1; CAG32995.1; CAG46794.1; AAH02772.1 

Protein Name

 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 

Protein Synonyms/Alias

 Complex I-B14; CI-B14; LYR motif-containing protein 6; NADH-ubiquinone oxidoreductase B14 subunit 

Gene Name

 NDUFA6 

Gene Synonyms/Alias

 LYRM6; NADHB14 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	STASTFVKPIFSRDM	ubiquitination	[1, 2]
111	VVDLLVIKGKIELEE	ubiquitination	[1, 2]
142	ETEAPRPKDFLSKFY	ubiquitination	[1, 2]
147	RPKDFLSKFYVGHDP	ubiquitination	[1, 2, 3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. 

Sequence Annotation

  

Keyword

 Complete proteome; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Respiratory chain; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0006979; P:response to oxidative stress; IDA:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR008011; Complex1_LYR.
 IPR016488; NADH_Ub_cplx-1_asu_su-6. 

Pfam

 PF05347; Complex1_LYR 

SMART

  

PROSITE

  

PRINTS