UniProt Accession

 NYV1_YEAST; Q12255; D6VY93 

Genbank Protein ID

 Z73265; U53876; AY692786; BK006945 

Genbank Nucleotide ID

 CAA97654.1; AAB67537.1; AAT92805.1; DAA09409.1 

Protein Name

 Vacuolar v-SNARE NYV1 

Protein Synonyms/Alias

 R-SNARE NYV1; New v-SNARE 1; Synaptobrevin NYV1 

Gene Name

 NYV1 

Gene Synonyms/Alias

 MAM2; YLR093C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
202	RVSLLVDKTSQLNSS	ubiquitination	[1]
212	QLNSSSNKFRRKAVN	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Vacuolar v-SNARE required for docking. Only involved in homotypic vacuole fusion. Required for Ca(2+) efflux from the vacuolar lumen, a required signal for subsequent membrane fusion events, by inhibiting vacuolar Ca(2+)-ATPase PMC1 and promoting Ca(2+) release when forming trans-SNARE assemblies during the docking step. 

Sequence Annotation

 DOMAIN 167 227 v-SNARE coiled-coil homology.  

Keyword

 3D-structure; Coiled coil; Complete proteome; Direct protein sequencing; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Vacuole. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 253 AA 

Protein Sequence

Gene Ontology

 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031201; C:SNARE complex; IDA:SGD.
 GO:0005484; F:SNAP receptor activity; IDA:SGD.
 GO:0042144; P:vacuole fusion, non-autophagic; IDA:SGD.
 GO:0006906; P:vesicle fusion; IDA:SGD. 

Interpro

 IPR001388; Synaptobrevin.
 IPR019005; Vacuolar_R-SNAR_Nyv1_N. 

Pfam

 PF09426; Nyv1_N
 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.