UniProt Accession

 H2A2_SCHPO; P04910 

Genbank Protein ID

 M11500; X05221; CU329670 

Genbank Nucleotide ID

 AAA35310.1; CAA28849.1; CAB10117.1 

Protein Name

 Histone H2A-beta 

Protein Synonyms/Alias

 H2A.2 

Gene Name

 hta2 

Gene Synonyms/Alias

 SPAC19G12.06c 

Created Date

 July 27, 2013 

Organism

 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 

NCBI Taxa ID

 284812 

Lysine Modification

Position	Peptide	Type	References
5	***MSGGKSGGKAAV	acetylation	[1]
9	SGGKSGGKAAVAKSA	acetylation	[1]
124	LLPKQSGKGKPSQEL	acetylation	[1]

Reference

 [1] Mapping Post-translational Modifications of Histones H2A, H2B and H4 in Schizosaccharomyces pombe.
 Xiong L, Wang Y.
 Int J Mass Spectrom. 2011 Mar 30;301(1-3):159-165. [PMID: 21516229] 

Functional Description

 Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOTIF 128 129 [ST]-Q motif.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 5 5 N6-acetyllysine (By similarity).
 MOD_RES 9 9 N6-acetyllysine (By similarity).
 MOD_RES 128 128 Phosphoserine.  

Keyword

 Acetylation; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 131 AA 

Protein Sequence

Gene Ontology

 GO:0031618; C:nuclear centromeric heterochromatin; IDA:PomBase.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006975; P:DNA damage induced protein phosphorylation; IMP:PomBase.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0034501; P:protein localization to kinetochore; IMP:PomBase.
 GO:0042770; P:signal transduction in response to DNA damage; IMP:PomBase. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.