Tag | Content |
---|
CPLM ID | CPLM-029100 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Obscurin |
Protein Synonyms/Alias | |
Gene Name | OBSCN |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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5594 | KRRALLYKRHNLAQV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | |
Sequence Annotation | |
Keyword | ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 5602 AA |
Protein Sequence | MLVIRGASLK DAGEYTCEVE ASKSTASLHV EEKANCFTEE LTNLQVEEKG TAVFTCKTEH 60 PAATVTWRKG LLELRASGKH QPSQEGLTLR LTISALEKAD SDTYTCDIGQ AQSRAQLLVQ 120 GRRVHIIEDL EDVDVQEGSS ATFRCRISPA NYEPVHWFLD KTPLHANELN EIDAQPGGYH 180 VLTLRQLALK DSGTIYFEAG DQRASAALRV TEKPSVFSRE LTDATITEGE DLTLVCETST 240 CDIPVCWTKD GKTLRGSARC QLSHEGHRAQ LLITGATLQD SGRYKCEAGG ACSSSIVRVH 300 ARPVRFQEAL KDLEVLEGGA ATLRCVLSSV AAPVKWCYGN NVLRPGDKYS LRQEGAMLEL 360 VVRNLRPQDS GRYSCSFGDQ TTSATLTVTA LPAQFIGKLR NKEATEGATA TLRCELSKAA 420 PVEWRKGSET LRDGDRYCLR QDGAMCELQI RGLAMVDAAE YSCVCGEERT SASLTIRPMP 480 AHFIGRLRHQ ESIEGATATL RCELSKAAPV EWRKGRESLR DGDRHSLRQD GAVCELQICG 540 LAVADAGEYS CVCGEERTSA TLTVKALPAK FTEGLRNEEA VEGATAMLWC ELSKVAPVEW 600 RKGPENLRDG DRYILRQEGT RCELQICGLA MADAGEYLCV CGQERTSATL TIRALPARFI 660 EDVKNQEARE GATAVLQCEL NSAAPVEWRK GSETLRDGDR YSLRQDGTKC ELQIRGLAMA 720 DTGEYSCVCG QERTSAMLTV RALPIKFTEG LRNEEATEGA TAVLRCELSK MAPVEWWKGH 780 ETLRDGDRHS LRQDGARCEL QIRGLVAEDA GEYLCMCGKE RTSAMLTVRA MPSKFIEGLR 840 NEEATEGDTA TLWCELSKAA PVEWRKGHET LRDGDRHSLR QDGSRCELQI RGLAVVDAGE 900 YSCVCGQERT SATLTVRALP ARFIEDVKNQ EAREGATAVL QCELSKAAPV EWRKGSETLR 960 GGDRYSLRQD GTRCELQIHG LSVADTGEYS CVCGQERTSA TLTVRALPAR FTQDLKTKEA 1020 SEGATATLQC ELSKVAPVEW KKGPETLRDG GRYSLKQDGT RCELQIHDLS VADAGEYSCM 1080 CGQERTSATL TVRALPARFT EGLRNEEAME GATATLQCEL SKAAPVEWRK GLEALRDGDK 1140 YSLRQDGAVC ELQIHGLAMA DNGVYSCVCG QERTSATLTV RALPARFIED MRNQKATEGA 1200 TVTLQCKLRK AAPVEWRKGP NTLKDGDRYS LKQDGTSCEL QIRGLVIADA GEYSCICEQE 1260 RTSATLTVRA LPARFIEDVR NHEATEGATA VLQCELSKAA PVEWRKGSET LRDGDRYSLR 1320 QDGTRCELQI RGLAVEDTGE YLCVCGQERT SATLTVRALP ARFIDNMTNQ EAREGATATL 1380 HCELSKVAPV EWRKGPETLR DGDRHSLRQD GTRCELQIRG LSVADAGEYS CVCGQERTSA 1440 TLTIREATEG ATAMLQCELS KVAPVEWRKG PETLRDGDRY NLRQDGTRCE LQIHGLSVAD 1500 TGEYSCVCGQ EKTSATLTVK APQPVFREPL QSLQAEEGST ATLQCELSEP TATVVWSKGG 1560 LQLQANGRRE PRLQGCTAEL VLQDLQREDT GEYTCTCGSQ ATSATLTVTA APVRFLRELQ 1620 HQEVDEGGTA HLCCELSRAG ASVEWRKGSL QLFPCAKYQM VQDGAAAELL VRGVEQEDAG 1680 DYTCDTGHTQ SMASLSVRVP RPKFKTRLQS LEQETGDIAR LCCQLSDAES GAVVQWLKEG 1740 VELHAGPKYE MRSQGATREL LIHQLEAKDT GEYACVTGGQ KTAASLRVTE PEVTIVRGLV 1800 DAEVTADEDV EFSCEVSRAG ATGVQWCLQG LPLQSNEVTE VAVRDGRIHT LRLKGVTPED 1860 AGTVSFHLGN HASSAQLTVR APEVTILEPL QDVQLSEGQD ASFQCRLSRA SGQEARWALG 1920 GVPLQANEMN DITVEQGTLH LLTLHKVTLE DAGTVSFHVG TCSSEAQLKV TAKNTVVRGL 1980 ENVEALEGGE ALFECQLSQP EVAAHTWLLD DEPVHTSENA EVVFFENGLR HLLLLKNLRP 2040 QDSCRVTFLA GDMVTSAFLT VRGWRLEILE PLKNAAVRAG AQACFTCTLS EAVPVGEASW 2100 YINGAAVQPD DSDWTVTADG SHHALLLRSA QPHHAGEVTF ACRDAVASAR LTVLGLPDPP 2160 EDAEVVARSS HTVTLSWAAP MSDGGGGLCG YRVEVKEGAT GQWRLCHELV PGPECVVDGL 2220 APGETYRFRV AAVGPVGAGE PVHLPQTVRL AEPPKPVPPQ PSAPESRQVA AGEDVSLELE 2280 VVAEAGEVIW HKGMERIQPG GRFEVVSQGR QQMLVIKGFT AEDQGEYHCG LAQGSICPAA 2340 ATFQVALSPA SVDEAPQPSL PPEAAQEGDL HLLWEALARK RRMSREPTLD SISELPEEDG 2400 RSQRLPQEAE EVAPDLSEGY STADELARTG DADLSHTSSD DESRAGTPSL VTYLKKAGRP 2460 GTSPLASKVG APAAPSVKPQ QQQEPLAAVR PPLGDLSTKD LGDPSMDKAA VKIQAAFKGY 2520 KVRKEMKQQE GPMFSHTFGD TEAQVGDALR LECVVASKAD VRARWLKDGV ELTDGRHHHI 2580 DQLGDGTCSL LITGLDRADA GCYTCQVSNK FGQVTHSACV VVSGSESEAE SSSGGELDDA 2640 FRRAARRLHR LFRTKSPAEV SDEELFLSAD EGPAEPEEPA DWQTYREDEH FICIRFEALT 2700 EARQAVTRFQ EMFATLGIGV EIKLVEQGPR RVEMCISKET PAPVVPPEPL PSLLTSDAAP 2760 VFLTELQNQE VQDGYPVSFD CVVTGQPMPS VRWFKDGKLL EEDDHYMINE DQQGGHQLII 2820 TAVVPADMGV YRCLAENSMG VSSTKAELRV DLTSTDYDTA ADATESSSYF SAQGYLSSRE 2880 QEGTESTTDE GQLPQVVEEL RDLQVAPGTR LAKFQLKVKG YPAPRLYWFK DGQPLTASAH 2940 IRMTDKKILH TLEIISVTRE DSGQYAAYIS NAMGAAYSSA RLLVRGPDEP EEKPASDVHE 3000 QLVPPRMLER FTPKKVKKGS SITFSVKVEG RPVPTVHWLR EEAERGVLWI GPDTPGYTVA 3060 SSAQQHSLVL LDVGRQHQGT YTCIASNAAG QALCSASLHV SGLPKVEEQE KVKEALISTF 3120 LQGTTQAISA QGLETASFAD LGGQRKEEPL AAKEALGHLS LAEVGTEEFL QKLTSQITEM 3180 VSAKITQAKL QVPGGDSDED SKTPSASPRH GRSRPSSSIQ ESSSESEDGD ARGEIFDIYV 3240 VTADYLPLGA EQDAITLREG QYVEVLDAAH PLRWLVRTKP TKSSPSRQGW VSPAYLDRRL 3300 KLSPEWGAAE APEFPGEAVS EDEYKARLSS VIQELLSSEQ AFVEELQFLQ SHHLQHLERC 3360 PHVPIAVAGQ KAVIFRNVRD IGRFHSSFLQ ELQQCDTDDD VAMCFIKNQA AFEQYLEFLV 3420 GRVQAESVVV STAIQEFYKK YAEEALLAGD PSQPPPPPLQ HYLEQPVERV QRYQALLKEL 3480 IRNKARNRQN CALLEQAYAV VSALPQRAEN KLHVSLMENY PGTLQALGEP IRQGHFIVWE 3540 GAPGARMPWK GHNRHVFLFR NHLVICKPRR DSRTDTVSYV FRNMMKLSSI DLNDQVEGDD 3600 RAFEVWQERE DSVRKYLLQA RTAIIKSSWV KEICGIQQRL ALPVWRPPDF EEELADCTAE 3660 LGETVKLACR VTGTPKPVIS WYKDGKAVQV DPHHILIEDP DGSCALILDS LTGVDSGQYM 3720 CFAASAAGNC STLGKILVQV PPRFVNKVRA SPFVEGEDAQ FTCTIEGAPY PQIRWYKDGA 3780 LLTTGNKFQT LSEPRSGLLV LVIRAASKED LGLYECELVN RLGSARASAE LRIQSPMLQA 3840 QEQCHREQLV AAVEDTTLER ADQEVTSVLK RLLGPKAPGP STGDLTGPGP CPRGAPALQE 3900 TGSQPPVTGT SEAPAVPPRV PQPLLHEGPE QEPEAIARAQ EWTVPIRMEG AAWPGAGTGE 3960 LLWDVHSHVV RETTQRTYTY QAIDTHTARP PSMQVTIEDV QAQTGGTAQF EAIIEGDPQP 4020 SVTWYKDSVQ LVDSTRLSQQ QEGTTYSLVL RHVASKDAGV YTCLAQNTGG QVLCKAELLV 4080 LGGDNEPDSE KQSHRRKLHS FYEVKEEIGR GVFGFVKRVQ HKGNKILCAA KFIPLRSRTR 4140 AQAYRERDIL AALSHPLVTG LLDQFETRKT LILILELCSS EELLDRLYRK GVVTEAEVKV 4200 YIQQLVEGLH YLHSHGVLHL DIKPSNILMV HPAREDIKIC DFGFAQNITP AELQFSQYGS 4260 PEFVSPEIIQ QNPVSEASDI WAMGVISYLS LTCSSPFAGE SDRATLLNVL EGRVSWSSPM 4320 AAHLSEDAKD FIKATLQRAP QARPSAAQCL SHPWFLKSMP AEEAHFINTK QLKFLLARSR 4380 WQRSLMSYKS ILVMRSIPEL LRGPPDSPSL GVARHLCRDT GGSSSSSSSS DNELAPFARA 4440 KSLPPSPVTH SPLLHPRGFL RPSASLPEEA EASERSTEAP APPASPEGAG PPAAQGCVPR 4500 HSVIRSLFYH QAGESPEHGA LAPGSRRHPA RRRHLLKGGY IAGALPGLRE PLMEHRVLEE 4560 EAAREEQATL LAKAPSFETA LRLPASGTHL APGHSHSLEH DSPSTPRPSS EACGEAQRLP 4620 SAPSGGAPIR DMGHPQGSKQ LPSTGGHPGT AQPERPSPDS PWGQPAPFCH PKQGSAPQEG 4680 CSPHPAVAPC PPGSFPPGSC KEAPLVPSSP FLGQPQAPPA PAKASPPLDS KMGPGDISLP 4740 GRPKPGPCSS PGSASQASSS QVSSLRVGSS QVGTEPGPSL DAEGWTQEAE DLSDSTPTLQ 4800 RPQEQATMRK FSLGGRGGYA GVAGYGTFAF GGDAGGMLGQ GPMWARIAWA VSQSEEEEQE 4860 EARAESQSEE QQEARAESPL PQVSARPVPE VGRAPTRSSP EPTPWEDIGQ VSLVQIRDLS 4920 GDAEAADTIS LDISEVDPAY LNLSDLYDIK YLPFEFMIFR KVPKSAQPEP PSPMAEEELA 4980 EFPEPTWPWP GELGPHAGLE ITEESEDVDA LLAEAAVGRK RKWSSPSRSL FHFPGRHLPL 5040 DEPAELGLRE RVKASVEHIS RILKGRPEGL EKEGPPRKKP GLASFRLSGL KSWDRAPTFL 5100 RELSDETVVL GQSVTLACQV SAQPAAQATW SKDGAPLESS SRVLISATLK NFQLLTILVV 5160 VAEDLGVYTC SVSNALGTVT TTGVLRKAER PSSSPCPDIG EVYADGVLLV WKPVESYGPV 5220 TYIVQCSLEG GSWTTLASDI FDCCYLTSKL SRGGTYTFRT ACVSKAGMGP YSSPSEQVLL 5280 GGPSHLASEE ESQGRSAQPL PSTKTFAFQT QIQRGRFSVV RQCWEKASGR ALAAKIIPYH 5340 PKDKTAVLRE YEALKGLRHP HLAQLHAAYL SPRHLVLILE LCSGPELLPC LAERASYSES 5400 EVKDYLWQML SATQYLHNQH ILHLDLRSEN MIITEYNLLK VVDLGNAQSL SQEKVLPSDK 5460 FKDYLETMAP ELLEGQGAVP QTDIWAIGVT AFIMLSAEYP VSSEGARDLQ RGLRKGLVRL 5520 SRCYAGLSGG AVAFLRSTLC AQPWGRPCAS SCLQCPWLTE EGPACSRPAP VTFPTARLRV 5580 FVRNREKRRA LLYKRHNLAQ VR 5602 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |