CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029100
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Obscurin 
Protein Synonyms/Alias
  
Gene Name
 OBSCN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5594KRRALLYKRHNLAQVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5602 AA 
Protein Sequence
MLVIRGASLK DAGEYTCEVE ASKSTASLHV EEKANCFTEE LTNLQVEEKG TAVFTCKTEH 60
PAATVTWRKG LLELRASGKH QPSQEGLTLR LTISALEKAD SDTYTCDIGQ AQSRAQLLVQ 120
GRRVHIIEDL EDVDVQEGSS ATFRCRISPA NYEPVHWFLD KTPLHANELN EIDAQPGGYH 180
VLTLRQLALK DSGTIYFEAG DQRASAALRV TEKPSVFSRE LTDATITEGE DLTLVCETST 240
CDIPVCWTKD GKTLRGSARC QLSHEGHRAQ LLITGATLQD SGRYKCEAGG ACSSSIVRVH 300
ARPVRFQEAL KDLEVLEGGA ATLRCVLSSV AAPVKWCYGN NVLRPGDKYS LRQEGAMLEL 360
VVRNLRPQDS GRYSCSFGDQ TTSATLTVTA LPAQFIGKLR NKEATEGATA TLRCELSKAA 420
PVEWRKGSET LRDGDRYCLR QDGAMCELQI RGLAMVDAAE YSCVCGEERT SASLTIRPMP 480
AHFIGRLRHQ ESIEGATATL RCELSKAAPV EWRKGRESLR DGDRHSLRQD GAVCELQICG 540
LAVADAGEYS CVCGEERTSA TLTVKALPAK FTEGLRNEEA VEGATAMLWC ELSKVAPVEW 600
RKGPENLRDG DRYILRQEGT RCELQICGLA MADAGEYLCV CGQERTSATL TIRALPARFI 660
EDVKNQEARE GATAVLQCEL NSAAPVEWRK GSETLRDGDR YSLRQDGTKC ELQIRGLAMA 720
DTGEYSCVCG QERTSAMLTV RALPIKFTEG LRNEEATEGA TAVLRCELSK MAPVEWWKGH 780
ETLRDGDRHS LRQDGARCEL QIRGLVAEDA GEYLCMCGKE RTSAMLTVRA MPSKFIEGLR 840
NEEATEGDTA TLWCELSKAA PVEWRKGHET LRDGDRHSLR QDGSRCELQI RGLAVVDAGE 900
YSCVCGQERT SATLTVRALP ARFIEDVKNQ EAREGATAVL QCELSKAAPV EWRKGSETLR 960
GGDRYSLRQD GTRCELQIHG LSVADTGEYS CVCGQERTSA TLTVRALPAR FTQDLKTKEA 1020
SEGATATLQC ELSKVAPVEW KKGPETLRDG GRYSLKQDGT RCELQIHDLS VADAGEYSCM 1080
CGQERTSATL TVRALPARFT EGLRNEEAME GATATLQCEL SKAAPVEWRK GLEALRDGDK 1140
YSLRQDGAVC ELQIHGLAMA DNGVYSCVCG QERTSATLTV RALPARFIED MRNQKATEGA 1200
TVTLQCKLRK AAPVEWRKGP NTLKDGDRYS LKQDGTSCEL QIRGLVIADA GEYSCICEQE 1260
RTSATLTVRA LPARFIEDVR NHEATEGATA VLQCELSKAA PVEWRKGSET LRDGDRYSLR 1320
QDGTRCELQI RGLAVEDTGE YLCVCGQERT SATLTVRALP ARFIDNMTNQ EAREGATATL 1380
HCELSKVAPV EWRKGPETLR DGDRHSLRQD GTRCELQIRG LSVADAGEYS CVCGQERTSA 1440
TLTIREATEG ATAMLQCELS KVAPVEWRKG PETLRDGDRY NLRQDGTRCE LQIHGLSVAD 1500
TGEYSCVCGQ EKTSATLTVK APQPVFREPL QSLQAEEGST ATLQCELSEP TATVVWSKGG 1560
LQLQANGRRE PRLQGCTAEL VLQDLQREDT GEYTCTCGSQ ATSATLTVTA APVRFLRELQ 1620
HQEVDEGGTA HLCCELSRAG ASVEWRKGSL QLFPCAKYQM VQDGAAAELL VRGVEQEDAG 1680
DYTCDTGHTQ SMASLSVRVP RPKFKTRLQS LEQETGDIAR LCCQLSDAES GAVVQWLKEG 1740
VELHAGPKYE MRSQGATREL LIHQLEAKDT GEYACVTGGQ KTAASLRVTE PEVTIVRGLV 1800
DAEVTADEDV EFSCEVSRAG ATGVQWCLQG LPLQSNEVTE VAVRDGRIHT LRLKGVTPED 1860
AGTVSFHLGN HASSAQLTVR APEVTILEPL QDVQLSEGQD ASFQCRLSRA SGQEARWALG 1920
GVPLQANEMN DITVEQGTLH LLTLHKVTLE DAGTVSFHVG TCSSEAQLKV TAKNTVVRGL 1980
ENVEALEGGE ALFECQLSQP EVAAHTWLLD DEPVHTSENA EVVFFENGLR HLLLLKNLRP 2040
QDSCRVTFLA GDMVTSAFLT VRGWRLEILE PLKNAAVRAG AQACFTCTLS EAVPVGEASW 2100
YINGAAVQPD DSDWTVTADG SHHALLLRSA QPHHAGEVTF ACRDAVASAR LTVLGLPDPP 2160
EDAEVVARSS HTVTLSWAAP MSDGGGGLCG YRVEVKEGAT GQWRLCHELV PGPECVVDGL 2220
APGETYRFRV AAVGPVGAGE PVHLPQTVRL AEPPKPVPPQ PSAPESRQVA AGEDVSLELE 2280
VVAEAGEVIW HKGMERIQPG GRFEVVSQGR QQMLVIKGFT AEDQGEYHCG LAQGSICPAA 2340
ATFQVALSPA SVDEAPQPSL PPEAAQEGDL HLLWEALARK RRMSREPTLD SISELPEEDG 2400
RSQRLPQEAE EVAPDLSEGY STADELARTG DADLSHTSSD DESRAGTPSL VTYLKKAGRP 2460
GTSPLASKVG APAAPSVKPQ QQQEPLAAVR PPLGDLSTKD LGDPSMDKAA VKIQAAFKGY 2520
KVRKEMKQQE GPMFSHTFGD TEAQVGDALR LECVVASKAD VRARWLKDGV ELTDGRHHHI 2580
DQLGDGTCSL LITGLDRADA GCYTCQVSNK FGQVTHSACV VVSGSESEAE SSSGGELDDA 2640
FRRAARRLHR LFRTKSPAEV SDEELFLSAD EGPAEPEEPA DWQTYREDEH FICIRFEALT 2700
EARQAVTRFQ EMFATLGIGV EIKLVEQGPR RVEMCISKET PAPVVPPEPL PSLLTSDAAP 2760
VFLTELQNQE VQDGYPVSFD CVVTGQPMPS VRWFKDGKLL EEDDHYMINE DQQGGHQLII 2820
TAVVPADMGV YRCLAENSMG VSSTKAELRV DLTSTDYDTA ADATESSSYF SAQGYLSSRE 2880
QEGTESTTDE GQLPQVVEEL RDLQVAPGTR LAKFQLKVKG YPAPRLYWFK DGQPLTASAH 2940
IRMTDKKILH TLEIISVTRE DSGQYAAYIS NAMGAAYSSA RLLVRGPDEP EEKPASDVHE 3000
QLVPPRMLER FTPKKVKKGS SITFSVKVEG RPVPTVHWLR EEAERGVLWI GPDTPGYTVA 3060
SSAQQHSLVL LDVGRQHQGT YTCIASNAAG QALCSASLHV SGLPKVEEQE KVKEALISTF 3120
LQGTTQAISA QGLETASFAD LGGQRKEEPL AAKEALGHLS LAEVGTEEFL QKLTSQITEM 3180
VSAKITQAKL QVPGGDSDED SKTPSASPRH GRSRPSSSIQ ESSSESEDGD ARGEIFDIYV 3240
VTADYLPLGA EQDAITLREG QYVEVLDAAH PLRWLVRTKP TKSSPSRQGW VSPAYLDRRL 3300
KLSPEWGAAE APEFPGEAVS EDEYKARLSS VIQELLSSEQ AFVEELQFLQ SHHLQHLERC 3360
PHVPIAVAGQ KAVIFRNVRD IGRFHSSFLQ ELQQCDTDDD VAMCFIKNQA AFEQYLEFLV 3420
GRVQAESVVV STAIQEFYKK YAEEALLAGD PSQPPPPPLQ HYLEQPVERV QRYQALLKEL 3480
IRNKARNRQN CALLEQAYAV VSALPQRAEN KLHVSLMENY PGTLQALGEP IRQGHFIVWE 3540
GAPGARMPWK GHNRHVFLFR NHLVICKPRR DSRTDTVSYV FRNMMKLSSI DLNDQVEGDD 3600
RAFEVWQERE DSVRKYLLQA RTAIIKSSWV KEICGIQQRL ALPVWRPPDF EEELADCTAE 3660
LGETVKLACR VTGTPKPVIS WYKDGKAVQV DPHHILIEDP DGSCALILDS LTGVDSGQYM 3720
CFAASAAGNC STLGKILVQV PPRFVNKVRA SPFVEGEDAQ FTCTIEGAPY PQIRWYKDGA 3780
LLTTGNKFQT LSEPRSGLLV LVIRAASKED LGLYECELVN RLGSARASAE LRIQSPMLQA 3840
QEQCHREQLV AAVEDTTLER ADQEVTSVLK RLLGPKAPGP STGDLTGPGP CPRGAPALQE 3900
TGSQPPVTGT SEAPAVPPRV PQPLLHEGPE QEPEAIARAQ EWTVPIRMEG AAWPGAGTGE 3960
LLWDVHSHVV RETTQRTYTY QAIDTHTARP PSMQVTIEDV QAQTGGTAQF EAIIEGDPQP 4020
SVTWYKDSVQ LVDSTRLSQQ QEGTTYSLVL RHVASKDAGV YTCLAQNTGG QVLCKAELLV 4080
LGGDNEPDSE KQSHRRKLHS FYEVKEEIGR GVFGFVKRVQ HKGNKILCAA KFIPLRSRTR 4140
AQAYRERDIL AALSHPLVTG LLDQFETRKT LILILELCSS EELLDRLYRK GVVTEAEVKV 4200
YIQQLVEGLH YLHSHGVLHL DIKPSNILMV HPAREDIKIC DFGFAQNITP AELQFSQYGS 4260
PEFVSPEIIQ QNPVSEASDI WAMGVISYLS LTCSSPFAGE SDRATLLNVL EGRVSWSSPM 4320
AAHLSEDAKD FIKATLQRAP QARPSAAQCL SHPWFLKSMP AEEAHFINTK QLKFLLARSR 4380
WQRSLMSYKS ILVMRSIPEL LRGPPDSPSL GVARHLCRDT GGSSSSSSSS DNELAPFARA 4440
KSLPPSPVTH SPLLHPRGFL RPSASLPEEA EASERSTEAP APPASPEGAG PPAAQGCVPR 4500
HSVIRSLFYH QAGESPEHGA LAPGSRRHPA RRRHLLKGGY IAGALPGLRE PLMEHRVLEE 4560
EAAREEQATL LAKAPSFETA LRLPASGTHL APGHSHSLEH DSPSTPRPSS EACGEAQRLP 4620
SAPSGGAPIR DMGHPQGSKQ LPSTGGHPGT AQPERPSPDS PWGQPAPFCH PKQGSAPQEG 4680
CSPHPAVAPC PPGSFPPGSC KEAPLVPSSP FLGQPQAPPA PAKASPPLDS KMGPGDISLP 4740
GRPKPGPCSS PGSASQASSS QVSSLRVGSS QVGTEPGPSL DAEGWTQEAE DLSDSTPTLQ 4800
RPQEQATMRK FSLGGRGGYA GVAGYGTFAF GGDAGGMLGQ GPMWARIAWA VSQSEEEEQE 4860
EARAESQSEE QQEARAESPL PQVSARPVPE VGRAPTRSSP EPTPWEDIGQ VSLVQIRDLS 4920
GDAEAADTIS LDISEVDPAY LNLSDLYDIK YLPFEFMIFR KVPKSAQPEP PSPMAEEELA 4980
EFPEPTWPWP GELGPHAGLE ITEESEDVDA LLAEAAVGRK RKWSSPSRSL FHFPGRHLPL 5040
DEPAELGLRE RVKASVEHIS RILKGRPEGL EKEGPPRKKP GLASFRLSGL KSWDRAPTFL 5100
RELSDETVVL GQSVTLACQV SAQPAAQATW SKDGAPLESS SRVLISATLK NFQLLTILVV 5160
VAEDLGVYTC SVSNALGTVT TTGVLRKAER PSSSPCPDIG EVYADGVLLV WKPVESYGPV 5220
TYIVQCSLEG GSWTTLASDI FDCCYLTSKL SRGGTYTFRT ACVSKAGMGP YSSPSEQVLL 5280
GGPSHLASEE ESQGRSAQPL PSTKTFAFQT QIQRGRFSVV RQCWEKASGR ALAAKIIPYH 5340
PKDKTAVLRE YEALKGLRHP HLAQLHAAYL SPRHLVLILE LCSGPELLPC LAERASYSES 5400
EVKDYLWQML SATQYLHNQH ILHLDLRSEN MIITEYNLLK VVDLGNAQSL SQEKVLPSDK 5460
FKDYLETMAP ELLEGQGAVP QTDIWAIGVT AFIMLSAEYP VSSEGARDLQ RGLRKGLVRL 5520
SRCYAGLSGG AVAFLRSTLC AQPWGRPCAS SCLQCPWLTE EGPACSRPAP VTFPTARLRV 5580
FVRNREKRRA LLYKRHNLAQ VR 5602 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR011009; Kinase-like_dom.
 IPR020675; Myosin_light_ch_kinase-rel.
 IPR020682; Obscurin-myosin_light-ch_kin.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR001452; SH3_domain.
 IPR008266; Tyr_kinase_AS. 
Pfam
 PF00041; fn3
 PF07679; I-set
 PF00612; IQ
 PF00069; Pkinase
 PF00621; RhoGEF 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2
 SM00015; IQ
 SM00233; PH
 SM00220; S_TKc
 SM00326; SH3 
PROSITE
 PS50010; DH_2
 PS50853; FN3
 PS50835; IG_LIKE
 PS50096; IQ
 PS50003; PH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS00109; PROTEIN_KINASE_TYR 
PRINTS