UniProt Accession

 RASH_MOUSE; Q61411; Q6P716; Q80WD2; Q811B9 

Genbank Protein ID

 Z50013; AC108908; BC061885; S74119; AJ437023 

Genbank Nucleotide ID

 CAA90306.1; AAH61885.1; AAP21090.1; CAD24593.1 

Protein Name

 GTPase HRas 

Protein Synonyms/Alias

 H-Ras-1; Transforming protein p21; c-H-ras; p21ras; GTPase HRas, N-terminally processed 

Gene Name

 Hras1 

Gene Synonyms/Alias

 Hras 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
101	HQYREQIKRVKDSDD	ubiquitination	[1]
147	PYIETSAKTRQGVED	ubiquitination	[1]
170	IRQHKLRKLNPPDES	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 116 119 GTP (By similarity).
 REGION 166 185 Hypervariable region.
 MOTIF 32 40 Effector region.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylthreonine; in GTPase HRas, N-
 MOD_RES 118 118 S-nitrosocysteine (By similarity).
 MOD_RES 186 186 Cysteine methyl ester (By similarity).
 LIPID 181 181 S-palmitoyl cysteine (By similarity).
 LIPID 184 184 S-(15-deoxy-Delta12,14-prostaglandin J2-
 LIPID 184 184 S-palmitoyl cysteine; alternate (By
 LIPID 186 186 S-farnesyl cysteine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Prenylation; Proto-oncogene; Reference proteome; S-nitrosylation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005525; F:GTP binding; IDA:MGI.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0007569; P:cell aging; IDA:MGI.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0008283; P:cell proliferation; IPI:MGI.
 GO:0090398; P:cellular senescence; IEA:Compara.
 GO:0006897; P:endocytosis; IDA:MGI.
 GO:0006917; P:induction of apoptosis; IGI:MGI.
 GO:0097193; P:intrinsic apoptotic signaling pathway; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IDA:MGI.
 GO:0034259; P:negative regulation of Rho GTPase activity; IEA:Compara.
 GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IDA:MGI.
 GO:0046330; P:positive regulation of JNK cascade; IEA:Compara.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:2000630; P:positive regulation of miRNA metabolic process; IEA:Compara.
 GO:0032855; P:positive regulation of Rac GTPase activity; IEA:Compara.
 GO:0046579; P:positive regulation of Ras protein signal transduction; ISO:MGI.
 GO:1900029; P:positive regulation of ruffle assembly; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0090303; P:positive regulation of wound healing; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0007265; P:Ras protein signal transduction; TAS:MGI.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
 GO:0035176; P:social behavior; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.