UniProt Accession

 SFTA1_HUMAN; Q8IWL2; A8K3T8; B7ZW50; E3VLD8; E3VLD9; E3VLE0; E3VLE1; G5E9J3; P07714; Q14DV4; Q5RIR5; Q5RIR7; Q6PIT0; Q8TC19 

Genbank Protein ID

 M30838; M13686; HQ021433; HQ021434; HQ021435; HQ021436; HQ021437; HQ021438; HQ021439; HQ021440; HQ021441; HQ021442; AK290703; AY198391; BX248123; BX248123; BX248123; CH471083; CH471083; CH471083; BC029913; BC111570; BC171875 

Genbank Nucleotide ID

 AAA36510.1; AAA60211.1; ADO27676.1; ADO27677.1; ADO27678.1; ADO27679.1; ADO27680.1; ADO27681.1; ADO27682.1; ADO27683.1; ADO27684.1; ADO27685.1; BAF83392.1; AAO13486.1; CAI16065.1; CAI16066.1; CAI16067.1; EAW54657.1; EAW54651.1; EAW54658.1; AAH29913.1; AAI11571.1; AAI71875.1 

Protein Name

 Pulmonary surfactant-associated protein A1 

Protein Synonyms/Alias

 PSP-A; PSPA; SP-A; SP-A1; 35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-4 

Gene Name

 SFTPA1 

Gene Synonyms/Alias

 COLEC4; PSAP; SFTP1; SFTPA; SFTPA1B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	RDGRDGLKGDPGPPG	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. 

Sequence Annotation

 DOMAIN 28 100 Collagen-like.
 DOMAIN 132 248 C-type lectin.
 MOD_RES 21 21 N-acetylglutamate; partial.
 MOD_RES 30 30 4-hydroxyproline (By similarity).
 MOD_RES 33 33 4-hydroxyproline (By similarity).
 MOD_RES 36 36 4-hydroxyproline (By similarity).
 MOD_RES 42 42 4-hydroxyproline (By similarity).
 MOD_RES 54 54 4-hydroxyproline (By similarity).
 MOD_RES 57 57 4-hydroxyproline (By similarity).
 MOD_RES 63 63 4-hydroxyproline (By similarity).
 MOD_RES 67 67 4-hydroxyproline (By similarity).
 MOD_RES 70 70 4-hydroxyproline (By similarity).
 CARBOHYD 207 207 N-linked (GlcNAc...) (Probable).
 DISULFID 26 26 Interchain (Probable).
 DISULFID 155 246
 DISULFID 224 238  

Keyword

 Acetylation; Alternative splicing; Calcium; Collagen; Complete proteome; Disulfide bond; Extracellular matrix; Gaseous exchange; Glycoprotein; Hydroxylation; Lectin; Polymorphism; Reference proteome; Secreted; Signal; Surface film. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0005581; C:collagen; IEA:UniProtKB-KW.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0005319; F:lipid transporter activity; TAS:ProtInc.
 GO:0007585; P:respiratory gaseous exchange; IEA:UniProtKB-KW. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR018378; C-type_lectin_CS.
 IPR016187; C-type_lectin_fold.
 IPR008160; Collagen. 

Pfam

 PF01391; Collagen
 PF00059; Lectin_C 

SMART

 SM00034; CLECT 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2 

PRINTS