CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041995
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60 kDa SS-A/Ro ribonucleoprotein 
Protein Synonyms/Alias
 TROVE domain family, member 2, isoform CRA_a 
Gene Name
 TROVE2 
Gene Synonyms/Alias
 hCG_41054 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12ALLRNLGKMTANSVLubiquitination[1]
32EVSLVCEKLCNEKLLubiquitination[1, 2]
37CEKLCNEKLLKKARIacetylation[3]
37CEKLCNEKLLKKARIubiquitination[1, 3]
67HGLRGKLKWRPDEEIubiquitination[1, 3, 4, 5]
84ALDAAFYKTFKTVEPacetylation[3]
84ALDAAFYKTFKTVEPubiquitination[3, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 263 AA 
Protein Sequence
MPLTALLRNL GKMTANSVLE PGNSEVSLVC EKLCNEKLLK KARIHPFHIL IALETYKTGH 60
GLRGKLKWRP DEEILKALDA AFYKTFKTVE PTGKRFLLAV DVSASMNQRV LGSILNASTV 120
AAAMCMVVTR TEKDSYVVAF SDEMVPCPVT TDMTLQQVLM AMSQIPAGGT DCSLPMIWAQ 180
KTNTPADVFI VFTDNETFAG GVHPAIALRE YRKKMDIPAK LIVCGMTSNG FTIADPDDRG 240
MLDMCGFDTG ALDVIRNFTL DMI 263 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0030529; C:ribonucleoprotein complex; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0060271; P:cilium morphogenesis; IEA:Compara. 
Interpro
 IPR008858; TROVE.
 IPR018698; VWA-like_dom. 
Pfam
 PF09967; DUF2201
 PF05731; TROVE 
SMART
  
PROSITE
 PS50988; TROVE 
PRINTS