CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018765
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sideroflexin-2 
Protein Synonyms/Alias
  
Gene Name
 Sfxn2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
52WAKAVVEKSRMGLVPacetylation[1, 2]
207LIQGICVKDRNQNELacetylation[2]
207LIQGICVKDRNQNELubiquitination[3]
257LERLHLMKKVKVMHAacetylation[4]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Potential iron transporter. 
Sequence Annotation
  
Keyword
 Complete proteome; Ion transport; Iron; Iron transport; Membrane; Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 322 AA 
Protein Sequence
MEGDLSGFNI DAPRWDQCTF LGRVKHFFNI TDPRTVFASE QELDWAKAVV EKSRMGLVPP 60
GTQMEQLLYA KKLYDSAFHP DTGEKMNVIG RMSFQVPGGM LITGFMLQFY RTMPAVIFWQ 120
WVNQSFNALV NYTNRNAASP TSVRQMALSY FTATTTAVAT AVGMNMWTKR APPLVGRWVP 180
FAAVAAANCV NIPMMRQQEL IQGICVKDRN QNELGHSQRA AAVGIAQVVI SRITMAAPGM 240
ILLPVIMERL ERLHLMKKVK VMHAPLQVLL CGCFLLFMVP VACGLFPQEC ELSVSYLEPE 300
LRDTIKAKYG EQVLFVYFNK GL 322 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
 GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. 
Interpro
 IPR004686; Mtc. 
Pfam
 PF03820; Mtc 
SMART
  
PROSITE
  
PRINTS