UniProt Accession

 EME2_HUMAN; A4GXA9; Q8TEP2; Q96RY3 

Genbank Protein ID

 EF452422; AK074080; AE006639 

Genbank Nucleotide ID

 ABO21766.1; BAB84906.2; AAK61292.1 

Protein Name

 Probable crossover junction endonuclease EME2 

Protein Synonyms/Alias

  

Gene Name

 EME2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	ALAQYPLKQYRESQA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; DNA damage; DNA recombination; DNA repair; Endonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 

Interpro

 IPR006166; ERCC4_domain. 

Pfam

 PF02732; ERCC4 

SMART

 SM00891; ERCC4 

PROSITE

  

PRINTS