| Tag | Content |
|---|
| CPLM ID | CPLM-019663 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RUN and FYVE domain-containing protein 1 |
Protein Synonyms/Alias | FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; Zinc finger FYVE domain-containing protein 12 |
Gene Name | RUFY1 |
Gene Synonyms/Alias | RABIP4; ZFYVE12 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 63 | KSFIGQNKSFFGPLE | ubiquitination | [1] | | 200 | ITDVLDQKNYVEELN | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. |
Sequence Annotation | DOMAIN 139 271 RUN.
ZN_FING 642 700 FYVE-type.
REGION 615 625 Interaction with RAB4 (By similarity).
MOD_RES 389 389 Phosphotyrosine.
MOD_RES 400 400 Phosphotyrosine. |
Keyword | 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Endocytosis; Endosome; Lipid-binding; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 708 AA |
Protein Sequence | MMEERANLMH MMKLSIKVLL QSALSLGRSL DADHAPLQQF FVVMEHCLKH GLKVKKSFIG 60
QNKSFFGPLE LVEKLCPEAS DIATSVRNLP ELKTAVGRGR AWLYLALMQK KLADYLKVLI 120
DNKHLLSEFY EPEALMMEEE GMVIVGLLVG LNVLDANLCL KGEDLDSQVG VIDFSLYLKD 180
VQDLDGGKEH ERITDVLDQK NYVEELNRHL SCTVGDLQTK IDGLEKTNSK LQEELSAATD 240
RICSLQEEQQ QLREQNELIR ERSEKSVEIT KQDTKVELET YKQTRQGLDE MYSDVWKQLK 300
EEKKVRLELE KELELQIGMK TEMEIAMKLL EKDTHEKQDT LVALRQQLEE VKAINLQMFH 360
KAQNAESSLQ QKNEAITSFE GKTNQVMSSM KQMEERLQHS ERARQGAEER SHKLQQELGG 420
RIGALQLQLS QLHEQCSSLE KELKSEKEQR QALQRELQHE KDTSSLLRME LQQVEGLKKE 480
LRELQDEKAE LQKICEEQEQ ALQEMGLHLS QSKLKMEDIK EVNQALKGHA WLKDDEATHC 540
RQCEKEFSIS RRKHHCRNCG HIFCNTCSSN ELALPSYPKP VRVCDSCHTL LLQRCSSTAS 600 |
Gene Ontology | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0008289; F:lipid binding; IEA:UniProtKB-KW. GO:0008565; F:protein transporter activity; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0030100; P:regulation of endocytosis; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |