CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015767
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytoplasmic FMR1-interacting protein 1 
Protein Synonyms/Alias
 Specifically Rac1-associated protein 1; Sra-1; p140sra-1 
Gene Name
 CYFIP1 
Gene Synonyms/Alias
 KIAA0068 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
347RVSAAMYKSLELAIGubiquitination[1]
622KMKRLESKYAPLHLVubiquitination[1]
652REGDLLTKERLCCGLubiquitination[1]
779KMVERIRKFQILNDEubiquitination[1]
796TILDKYLKSGDGEGTubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. 
Sequence Annotation
  
Keyword
 3D-structure; Actin-binding; Alternative splicing; Cell junction; Cell projection; Cell shape; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Neurogenesis; Polymorphism; Reference proteome; Synapse; Synaptosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1253 AA 
Protein Sequence
MAESLGSAEL LRQLKSLGME RLLHAVNTFL RQSCTYLPLL TFGGKTSFVS LDVYGTEANC 60
SATSCSFPKA AATWPRRQAP GPLGELVRGP PDQGVAEQSF SHGLFEFGIT NVPCIFSPPQ 120
MFPWIIQLYM VRTMLESLIA DKSGSKKTLR SSLEGPTILD IEKFHRESFF YTHLINFSET 180
LQQCCDLSQL WFREFFLELT MGRRIQFPIE MSMPWILTDH ILETKEASMM EYVLYSLDLY 240
NDSAHYALTR FNKQFLYDEI EAEVNLCFDQ FVYKLADQIF AYYKVMAGSL LLDKRLRSEC 300
KNQGATIHLP PSNRYETLLK QRHVQLLGRS IDLNRLITQR VSAAMYKSLE LAIGRFESED 360
LTSIVELDGL LEINRMTHKL LSRYLTLDGF DAMFREANHN VSAPYGRITL HVFWELNYDF 420
LPNYCYNGST NRFVRTVLPF SQEFQRDKQP NAQPQYLHGS KALNLAYSSI YGSYRNFVGP 480
PHFQVICRLL GYQGIAVVME ELLKVVKSLL QGTILQYVKT LMEVMPKICR LPRHEYGSPG 540
ILEFFHHQLK DIVEYAELKT VCFQNLREVG NAILFCLLIE QSLSLEEVCD LLHAAPFQNI 600
LPRVHVKEGE RLDAKMKRLE SKYAPLHLVP LIERLGTPQQ IAIAREGDLL TKERLCCGLS 660
MFEVILTRIR SFLDDPIWRG PLPSNGVMHV DECVEFHRLW SAMQFVYCIP VGTHEFTVEQ 720
CFGDGLHWAG CMIIVLLGQQ RRFAVLDFCY HLLKVQKHDG KDEIIKNVPL KKMVERIRKF 780
QILNDEIITI LDKYLKSGDG EGTPVEHVRC FQPPIHQSLA SS 822 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030027; C:lamellipodium; ISS:UniProtKB.
 GO:0005845; C:mRNA cap binding complex; ISS:UniProtKB.
 GO:0043005; C:neuron projection; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0001726; C:ruffle; ISS:UniProtKB.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0051015; F:actin filament binding; ISS:UniProtKB.
 GO:0048365; F:Rac GTPase binding; ISS:UniProtKB.
 GO:0048675; P:axon extension; IMP:UniProtKB.
 GO:0030032; P:lamellipodium assembly; ISS:UniProtKB.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0031529; P:ruffle organization; ISS:UniProtKB. 
Interpro
 IPR008081; Cytoplasmic_FMR1-int.
 IPR016536; Cytoplasmic_FMR1-int_sub. 
Pfam
 PF05994; FragX_IP 
SMART
  
PROSITE
  
PRINTS
 PR01698; CYTOFMRPINTP.