UniProt Accession

 MP2K3_MOUSE; O09110; P97293; Q91VX1 

Genbank Protein ID

 X93150; D87115; AK011002; AK008141; BC007467 

Genbank Nucleotide ID

 CAA63649.1; BAA13247.1; BAB27321.1; BAB25489.1; AAH07467.1 

Protein Name

 Dual specificity mitogen-activated protein kinase kinase 3 

Protein Synonyms/Alias

 MAP kinase kinase 3; MAPKK 3; MAPK/ERK kinase 3; MEK 3 

Gene Name

 Map2k3 

Gene Synonyms/Alias

 Mkk3; Prkmk3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
80	GAYGVVEKVRHAQSG	ubiquitination	[1]
243	INPELNQKGYNVKSD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38 (By similarity). 

Sequence Annotation

 DOMAIN 64 325 Protein kinase.
 NP_BIND 70 78 ATP (By similarity).
 ACT_SITE 190 190 Proton acceptor (By similarity).
 BINDING 93 93 ATP (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 3 3 Phosphoserine (By similarity).
 MOD_RES 218 218 Phosphoserine (By similarity).
 MOD_RES 222 222 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004708; F:MAP kinase kinase activity; IDA:MGI.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
 GO:0060048; P:cardiac muscle contraction; IMP:MGI.
 GO:0006954; P:inflammatory response; IMP:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0042035; P:regulation of cytokine biosynthetic process; IMP:MGI. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS