CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012708
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fascin 
Protein Synonyms/Alias
 55 kDa actin-bundling protein; Singed-like protein; p55 
Gene Name
 FSCN1 
Gene Synonyms/Alias
 FAN1; HSN; SNL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
241SGPSGTLKAGKATKVubiquitination[1]
471KVGGRYLKGDHAGVLacetylation[2]
479GDHAGVLKASAETVDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. 
Sequence Annotation
 MOD_RES 2 2 N-acetylthreonine.
 MOD_RES 38 38 Phosphoserine.
 MOD_RES 39 39 Phosphoserine; by PKC.  
Keyword
 3D-structure; Acetylation; Actin-binding; Cell junction; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV 60
CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR WSLQSEAHRR YFGGTEDRLS 120
CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA 180
FQDQRYSVQT ADHRFLRHDG RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL 240
KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR 300
DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS NGKFVTSKKN 360
GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND 420
GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA 480
SAETVDPASL WEY 493 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030175; C:filopodium; IDA:UniProtKB.
 GO:0071437; C:invadopodium; IDA:UniProtKB.
 GO:0001725; C:stress fiber; IDA:UniProtKB.
 GO:0051015; F:actin filament binding; IDA:UniProtKB.
 GO:0008144; F:drug binding; IDA:UniProtKB.
 GO:0051017; P:actin filament bundle assembly; IDA:UniProtKB.
 GO:0016477; P:cell migration; IMP:UniProtKB.
 GO:0008283; P:cell proliferation; TAS:ProtInc. 
Interpro
 IPR008999; Actin_cross-linking.
 IPR010431; Fascin.
 IPR022768; Fascin-domain.
 IPR024703; Fascin_metazoans. 
Pfam
 PF06268; Fascin 
SMART
  
PROSITE
  
PRINTS