CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008420
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydroxy-acid dehydratase 
Protein Synonyms/Alias
 DAD; Vegetative protein 110; VEG110 
Gene Name
 ilvD 
Gene Synonyms/Alias
 BSU21870 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
360TIAGHEVKDYDVIHPacetylation[1]
523VPEEEWEKRKANWKGacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
  
Sequence Annotation
 METAL 122 122 Iron-sulfur (4Fe-4S) (Potential).
 METAL 195 195 Iron-sulfur (4Fe-4S) (Potential).  
Keyword
 4Fe-4S; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 558 AA 
Protein Sequence
MAELRSNMIT QGIDRAPHRS LLRAAGVKEE DFGKPFIAVC NSYIDIVPGH VHLQEFGKIV 60
KEAIREAGGV PFEFNTIGVD DGIAMGHIGM RYSLPSREII ADSVETVVSA HWFDGMVCIP 120
NCDKITPGML MAAMRINIPT IFVSGGPMAA GRTSDGRKIS LSSVFEGVGA YQAGKINENE 180
LQELEQFGCP TCGSCSGMFT ANSMNCLSEA LGLALPGNGT ILATSPERKE FVRKSAAQLM 240
ETIRKDIKPR DIVTVKAIDN AFALDMALGG STNTVLHTLA LANEAGVEYS LERINEVAER 300
VPHLAKLAPA SDVFIEDLHE AGGVSAALNE LSKKEGALHL DALTVTGKTL GETIAGHEVK 360
DYDVIHPLDQ PFTEKGGLAV LFGNLAPDGA IIKTGGVQNG ITRHEGPAVV FDSQDEALDG 420
IINRKVKEGD VVIIRYEGPK GGPGMPEMLA PTSQIVGMGL GPKVALITDG RFSGASRGLS 480
IGHVSPEAAE GGPLAFVENG DHIIVDIEKR ILDVQVPEEE WEKRKANWKG FEPKVKTGYL 540
ARYSKLVTSA NTGGIMKI 558 
Gene Ontology
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:HAMAP.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0009097; P:isoleucine biosynthetic process; IEA:HAMAP.
 GO:0009099; P:valine biosynthetic process; IEA:HAMAP. 
Interpro
 IPR015928; Aconitase/3IPM_dehydase_swvl.
 IPR004404; DihydroxyA_deHydtase.
 IPR000581; DiOHA_6PGluconate_deHydtase.
 IPR020558; DiOHA_6PGluconate_deHydtase_CS. 
Pfam
 PF00920; ILVD_EDD 
SMART
  
PROSITE
 PS00886; ILVD_EDD_1
 PS00887; ILVD_EDD_2 
PRINTS