| Tag | Content |
|---|
| CPLM ID | CPLM-003461 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA-cytosine methyltransferase |
Protein Synonyms/Alias | M.EcoDcm |
Gene Name | dcm |
Gene Synonyms/Alias | mec; b1961; JW1944 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 269 | DPKIIDGKHFLPQHR | acetylation | [1] | | 387 | WDMATGEKDFDDPLN | acetylation | [1] | | 420 | FEAPGEAKFRIPVSD | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands. |
Sequence Annotation | ACT_SITE 177 177 By similarity. |
Keyword | Complete proteome; Methyltransferase; Reference proteome; Restriction system; S-adenosyl-L-methionine; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 472 AA |
Protein Sequence | MQENISVTDS YSTGNAAQAM LEKLLQIYDV KTLVAQLNGV GENHWSAAIL KRALANDSAW 60
HRLSEKEFAH LQTLLPKPPA HHPHYAFRFI DLFAGIGGIR RGFESIGGQC VFTSEWNKHA 120
VRTYKANHYC DPATHHFNED IRDITLSHKE GVSDEAAAEH IRQHIPEHDV LLAGFPCQPF 180
SLAGVSKKNS LGRAHGFACD TQGTLFFDVV RIIDARRPAM FVLENVKNLK SHDQGKTFRI 240
IMQTLDELGY DVADAEDNGP DDPKIIDGKH FLPQHRERIV LVGFRRDLNL KADFTLRDIS 300
ECFPAQRVTL AQLLDPMVEA KYILTPVLWK YLYRYAKKHQ ARGNGFGYGM VYPNNPQSVT 360
RTLSARYYKD GAEILIDRGW DMATGEKDFD DPLNQQHRPR RLTPRECARL MGFEAPGEAK 420
FRIPVSDTQA YRQFGNSVVV PVFAAVAKLL EPKIKQAVAL RQQEAQHGRR SR 472 |
Gene Ontology | GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IDA:EcoCyc. GO:0003677; F:DNA binding; IEA:InterPro. GO:0009307; P:DNA restriction-modification system; IDA:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |