| Tag | Content |
|---|
| CPLM ID | CPLM-022583 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | GMP reductase 2 |
Protein Synonyms/Alias | Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2 |
Gene Name | GMPR2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 291 | EYRASEGKTVEVPFK | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation. |
Sequence Annotation | NP_BIND 108 131 NADP (By similarity).
ACT_SITE 186 186 Thioimidate intermediate (By similarity).
METAL 181 181 Potassium; via carbonyl oxygen (By
METAL 183 183 Potassium; via carbonyl oxygen (By
BINDING 219 219 NADP (By similarity).
MOD_RES 291 291 N6-acetyllysine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Metal-binding; NADP; Oxidoreductase; Polymorphism; Potassium; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 348 AA |
Protein Sequence | MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT 60
FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI 120
PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI 180
GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM 240
LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD 300
VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC 348 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0003920; F:GMP reductase activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0009117; P:nucleotide metabolic process; IEA:InterPro. GO:0006144; P:purine nucleobase metabolic process; TAS:Reactome. GO:0043101; P:purine-containing compound salvage; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |