CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030588
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RAN binding protein 1, isoform CRA_f 
Protein Synonyms/Alias
 Ran-specific GTPase-activating protein; cDNA FLJ40340 fis, clone TESTI2032681, moderately similar to RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 
Gene Name
 RANBP1 
Gene Synonyms/Alias
 hCG_17886 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
44DFADECPKPELLAIRacetylation[1]
44DFADECPKPELLAIRubiquitination[2, 3]
60LNAENAQKFKTKFEEacetylation[1, 4, 5, 6]
60LNAENAQKFKTKFEEubiquitination[1, 2, 3, 7, 8, 9]
64NAQKFKTKFEECRKEacetylation[1]
64NAQKFKTKFEECRKEubiquitination[3]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [7] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [8] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [9] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 181 AA 
Protein Sequence
MGGRSAQAGL GTRITPMMEL KPNAGSDRAW VWNTHADFAD ECPKPELLAI RFLNAENAQK 60
FKTKFEECRK EIEEREKKGD VVPWVGGLLC RLTLHLTILP GGCFFCLPDK HSRVLWPPHV 120
SRVMQLPGDT GASWGALSTC QCCWPQSNWA GIGVRALPGA HQKVLYDGPR FVSQRAWSPL 180
P 181 
Gene Ontology
 GO:0046907; P:intracellular transport; IEA:InterPro. 
Interpro
 IPR011993; PH_like_dom.
 IPR000156; Ran_bind_dom. 
Pfam
 PF00638; Ran_BP1 
SMART
 SM00160; RanBD 
PROSITE
 PS50196; RANBD1 
PRINTS