UniProt Accession

 ANXA6_MOUSE; P14824; Q8BSS4 

Genbank Protein ID

 X13460; AK030728; AK146509; AK146592 

Genbank Nucleotide ID

 CAA31808.1; BAC27101.1; BAE27222.1; BAE27287.1 

Protein Name

 Annexin A6 

Protein Synonyms/Alias

 67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70 

Gene Name

 Anxa6 

Gene Synonyms/Alias

 Anx6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKIAQGAMY	ubiquitination	[1]
34	EALYTAMKGFGSDKE	ubiquitination	[1]
40	MKGFGSDKESILELI	ubiquitination	[1]
63	QEICQNYKSLYGKDL	ubiquitination	[1]
68	NYKSLYGKDLIEDLK	ubiquitination	[1]
81	LKYELTGKFERLIVN	ubiquitination	[1]
99	PLAYCDAKEIKDAIS	ubiquitination	[1]
135	HQLVAAYKDAYERDL	ubiquitination	[1]
306	KSLYSMIKNDTSGEY	ubiquitination	[1]
370	FNPDADAKALRKAMK	ubiquitination	[1]
377	KALRKAMKGIGTDEA	ubiquitination	[1]
406	QQIRQTFKSHFGRDL	ubiquitination	[1]
442	PPAHYDAKQLKKAME	ubiquitination	[1]
456	EGAGTDEKTLIEILA	ubiquitination	[1]
478	RAINEAYKEDYHKSL	ubiquitination	[1]
483	AYKEDYHKSLEDALS	ubiquitination	[1]
600	IVQSVKNKPLFFADK	ubiquitination	[1]
607	KPLFFADKLYKSMKG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. 

Sequence Annotation

 REPEAT 29 89 Annexin 1.
 REPEAT 101 161 Annexin 2.
 REPEAT 185 245 Annexin 3.
 REPEAT 260 320 Annexin 4.
 REPEAT 372 432 Annexin 5.
 REPEAT 444 504 Annexin 6.
 REPEAT 533 593 Annexin 7.
 REPEAT 608 668 Annexin 8.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 30 30 Phosphotyrosine.
 MOD_RES 63 63 N6-acetyllysine (By similarity).
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 75 75 N6-acetyllysine (By similarity).
 MOD_RES 81 81 N6-acetyllysine (By similarity).
 MOD_RES 201 201 Phosphotyrosine.
 MOD_RES 306 306 N6-acetyllysine (By similarity).
 MOD_RES 370 370 N6-acetyllysine (By similarity).
 MOD_RES 418 418 N6-acetyllysine (By similarity).
 MOD_RES 483 483 N6-acetyllysine (By similarity).
 MOD_RES 620 620 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 673 AA 

Protein Sequence

Gene Ontology

 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0006816; P:calcium ion transport; IMP:MGI.
 GO:0006937; P:regulation of muscle contraction; IMP:MGI. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002393; AnnexinVI. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00202; ANNEXINVI.