CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033172
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rab3 GTPase-activating protein catalytic subunit 
Protein Synonyms/Alias
  
Gene Name
 RAB3GAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29EWERFISKVEEVLNDubiquitination[1]
38EEVLNDWKLIGNSLGubiquitination[1, 2]
46LIGNSLGKPLEKGIFubiquitination[1, 2, 3, 4]
50SLGKPLEKGIFTSGTubiquitination[2, 3]
197FEMVHLRKVPNQYTHubiquitination[1]
215LLDIFKSKIGCPLTPubiquitination[1]
316HWSVRVRKAENPQCLubiquitination[1]
338FFKICRRKESTDEILubiquitination[1]
355SAFEEEGKETADITHubiquitination[1]
366DITHALSKLTEPASVubiquitination[1]
377PASVPIHKLSVSNMVubiquitination[1]
389NMVHTAKKKIRKHRGubiquitination[1]
772LHYLAIQKPADLARHubiquitination[1]
857KAKFGTEKCEQEEEKubiquitination[1]
896HAGRIIHKLFVNAQRubiquitination[1, 2]
922TPPEEELKRMGSPEEubiquitination[1]
960PRPAPYSKALPQRMYubiquitination[1, 2]
972RMYSVLTKEDFRLAGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 988 AA 
Protein Sequence
MAADSEPESE VFEITDFTTA SEWERFISKV EEVLNDWKLI GNSLGKPLEK GIFTSGTWEE 60
KSDEISFADF KFSVTHHYLV QESTDKEGKD ELLEDVVPQS MQDLLGMNND FPPRAHCLVR 120
WYGLREFVVI APAAHSDAVL SESKCNLLLS SVSIALGNTG CQVPLFVQIH HKWRRMYVGE 180
CQGPGVRTDF EMVHLRKVPN QYTHLSGLLD IFKSKIGCPL TPLPPVSIAI RFTYVLQDWQ 240
QYFWPQQPPD IDALVGGEVG GLEFGKLPFG ACEDPISELH LATTWPHLTE GIIVDNDVYS 300
DLDPIQAPHW SVRVRKAENP QCLLGDFVTE FFKICRRKES TDEILGRSAF EEEGKETADI 360
THALSKLTEP ASVPIHKLSV SNMVHTAKKK IRKHRGVEES PLNNDVLNTI LLFLFPDAVS 420
EKPLDGTTST DNNNPPSESE DYNLYNQFKS APSDSLTYKL ALCLCMINFY HGGLKGVAHL 480
WQEFVLEMRF RWENNFLIPG LASGPPDLRC CLLHQKLQML NCCIERKKAR DEGKKTSASD 540
VTNIYPGDAG KAGDQLVPDN LKETDKEKGE VGKSWDSWSD SEEEFFECLS DTEELKGNGQ 600
ESGKKGGPKE MANLRPEGRL YQHGKLTLLH NGEPLYIPVT QEPAPMTEDL LEEQSEVLAK 660
LGTSAEGAHL RARMQSACLL SDMESFKAAN PGCSLEDFVR WYSPRDYIEE EVIDEKGNVV 720
LKGELSARMK IPSNMWVEAW ETAKPIPARR QRRLFDDTRE AEKVLHYLAI QKPADLARHL 780
LPCVIHAAVL KVKEEESLEN ISSVKKIIKQ IISHSSKVLH FPNPEDKKLE EIIHQITNVE 840
ALIARARSLK AKFGTEKCEQ EEEKEDLERF VSCLLEQPEV LVTGAGRGHA GRIIHKLFVN 900
AQRLTESSDE AAAMTPPEEE LKRMGSPEER RQNSVSDFPP PAGREFILRT TVPRPAPYSK 960
ALPQRMYSVL TKEDFRLAGA FSSDTSFF 988 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR026147; Rab3-GAP_cat_su. 
Pfam
 PF13890; Rab3-GTPase_cat 
SMART
  
PROSITE
  
PRINTS