UniProt Accession

 HMCS_YEAST; P54839; D6W0F9 

Genbank Protein ID

 X96617; Z50178; BK006946 

Genbank Nucleotide ID

 CAA65437.1; CAA90557.1; DAA09773.1 

Protein Name

 Hydroxymethylglutaryl-CoA synthase 

Protein Synonyms/Alias

 HMG-CoA synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase 

Gene Name

 ERG13 

Gene Synonyms/Alias

 HMGS; YML126C; YM4987.09C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
43	KQKTAEQKTRPQNVG	acetylation	[1]
110	TVLSKLIKSYNIDTN	acetylation	[1]
118	SYNIDTNKIGRLEVG	acetylation	[1]
118	SYNIDTNKIGRLEVG	ubiquitination	[2]
132	GTETLIDKSKSVKSV	acetylation	[1]
263	KALDQVYKSYSKKAI	acetylation	[1]
263	KALDQVYKSYSKKAI	ubiquitination	[2]
272	YSKKAISKGLVSDPA	ubiquitination	[2]
301	VFHVPTCKLVTKSYG	acetylation	[1]
301	VFHVPTCKLVTKSYG	ubiquitination	[2]
305	PTCKLVTKSYGRLLY	acetylation	[1]
305	PTCKLVTKSYGRLLY	ubiquitination	[2]
341	YDESLTDKNIEKTFV	acetylation	[1]
345	LTDKNIEKTFVNVAK	acetylation	[1]
352	KTFVNVAKPFHKERV	acetylation	[1]
425	GDVQHIIKELDITNK	acetylation	[1]
432	KELDITNKLAKRITE	acetylation	[1]
442	KRITETPKDYEAAIE	acetylation	[1]
461	AHLKKNFKPQGSIEH	acetylation	[1]
461	AHLKKNFKPQGSIEH	ubiquitination	[3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase (By similarity). 

Sequence Annotation

 ACT_SITE 159 159 Potential.
 MOD_RES 276 276 Phosphoserine.  

Keyword

 Complete proteome; Lipid biosynthesis; Lipid metabolism; Phosphoprotein; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 491 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IMP:SGD.
 GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. 

Interpro

 IPR000590; HMG_CoA_synt_AS.
 IPR013746; HMG_CoA_synt_C.
 IPR013528; HMG_CoA_synth_N.
 IPR010122; HMG_CoA_synthase_euk.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr. 

Pfam

 PF08540; HMG_CoA_synt_C
 PF01154; HMG_CoA_synt_N 

SMART

  

PROSITE

 PS01226; HMG_COA_SYNTHASE 

PRINTS