| Tag | Content |
|---|
| CPLM ID | CPLM-013169 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Complement C1r subcomponent-like protein |
Protein Synonyms/Alias | C1r-LP; C1r-like protein |
Gene Name | C1rl |
Gene Synonyms/Alias | C1rlp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 283 | AAHTIYPKDSIYLRR | ubiquitination | [1] | | 388 | TTKLKYSKLPVAPRE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum (By similarity). |
Sequence Annotation | DOMAIN 44 166 CUB.
DOMAIN 240 479 Peptidase S1.
ACT_SITE 278 278 Charge relay system (By similarity).
ACT_SITE 334 334 Charge relay system (By similarity).
ACT_SITE 431 431 Charge relay system (By similarity).
CARBOHYD 358 358 N-linked (GlcNAc...) (Potential).
DISULFID 97 115 By similarity.
DISULFID 397 416 By similarity.
DISULFID 427 457 By similarity. |
Keyword | Complement pathway; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Immunity; Innate immunity; Protease; Reference proteome; Secreted; Serine protease; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 482 AA |
Protein Sequence | MSGFRGLVPE LENSLWSSPT TSCMSKMCWW LLWGILHTCP TQASVLLAQQ SPQQLTSPGY 60
PEPYLKGQES HTDIEAPEGF AVRLTFQDFD LEPSPDCEGD SVTISTGGTD ATRLCGRQGS 120
PLGNPPGHRE FVSSGRSLRL TFQAHSSSKS KITHLHKGFL ALYQAVAVNQ PNGDTEAVTT 180
PGAPKIQNHC QDPYYKADQT GTLSCPSSWK WKDRQDGGEV PECVPVCGRP VVPLAENPNT 240
FGSSRAKLGN FPWQAFTSIY GRGGGALLGD RWILTAAHTI YPKDSIYLRR NQNVEVFLGH 300
TDIDELLKLG NHPVRRVVVH PDYRQHESHN FNGDIALLEL EQRVPLGPNL LPVCLPDNET 360
LYHSGLWGYV SGFGVEMGWL TTKLKYSKLP VAPREACEAW LHQRQRTEVF SDNMFCVGEE 420
MQVNSVCQGD SGSVYVVWDD LALRWVATGI VSWGIGCGKG YGFYTKVLSY MDWIKRVIEG 480
KD 482 |
Gene Ontology | GO:0005615; C:extracellular space; IDA:MGI. GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |