UniProt Accession

 CK054_MOUSE; Q91V76 

Genbank Protein ID

 AK088123; AK147073; CT010296; BC011540; BC016078 

Genbank Nucleotide ID

 BAC40160.1; BAE27654.1; CAJ18504.1; AAH11540.1; AAH16078.1 

Protein Name

 Ester hydrolase C11orf54 homolog 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
74	YLLPLVNKKKVYDLN	ubiquitination	[1]
75	LLPLVNKKKVYDLNE	phosphoglycerylation	[2]
76	LPLVNKKKVYDLNEI	acetylation	[3]
76	LPLVNKKKVYDLNEI	ubiquitination	[1]
85	YDLNEIAKVIKLPGA	ubiquitination	[1]
144	DGACLLEKYSQKYHD	ubiquitination	[1]
199	LEEHYGDKPVGMGGT	ubiquitination	[1]
211	GGTFIVQKGKVKAHI	ubiquitination	[1]
215	IVQKGKVKAHIMPAE	ubiquitination	[1]
244	WLHFYEMKAPLVCLP	ubiquitination	[1]
256	CLPVFVSKDPGLDLR	acetylation	[3]
256	CLPVFVSKDPGLDLR	ubiquitination	[1]
307	LYRIDQPKETHAFGR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Exhibits ester hydrolase activity on the substrate p- nitrophenyl acetate (By similarity). 

Sequence Annotation

 METAL 266 266 Zinc; catalytic (By similarity).
 METAL 268 268 Zinc; catalytic (By similarity).
 METAL 278 278 Zinc; catalytic (By similarity).  

Keyword

 Complete proteome; Hydrolase; Metal-binding; Nucleus; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR015021; DUF1907. 

Pfam

 PF08925; DUF1907 

SMART

  

PROSITE

  

PRINTS