| Tag | Content |
|---|
| CPLM ID | CPLM-017267 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Optineurin |
Protein Synonyms/Alias | |
Gene Name | Optn |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 443 | AEQALASKQLQMDEM | ubiquitination | [1] | | 451 | QLQMDEMKQTLAKQE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD) (By similarity). |
Sequence Annotation | REGION 415 524 Interaction with MYO6 (By similarity).
MOTIF 477 482 UBAN.
MOD_RES 187 187 Phosphoserine; by TBK1 (By similarity).
MOD_RES 210 210 Phosphothreonine.
MOD_RES 218 218 Phosphoserine.
MOD_RES 345 345 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Golgi apparatus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 584 AA |
Protein Sequence | MSHQPLSCLT EKGDSPCETP GNGPSNMVHP SLDTFTPEEL LQQMKELLVE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERLLFEMQS KEVKERLKAL THENERLKEE LGKFKEKSEK 120
PLEDLTGGYR YPRALEEEVE KLKTQVEQEV EHLKIQVMRL RAEKADLLGI VSELQLKLNS 180
GGSSEDSFVE IRMTEGETEG AMKEMKNCPT PTRTDPISLS NCTEDARSCA EFEELTVSQL 240
LLCLREGNQK VERLEVALRE AKERISDFEK KANGHSSTEK QTARRADREK EDKGQESVGS 300
EVETLSIQVT SLFKELQEAH TKLSEAELMK KRLQEKCQAL ERKNSATPSE LNEKQELVYS 360
NKKLELQVES MRSEIKMEQA KTEEEKSRLA TLQATHNKLL QEHNKALKTI EELTKQQAEK 420
VDKMLLQELS EKLELAEQAL ASKQLQMDEM KQTLAKQEED LETMAVLRAQ MEVYCSDFHA 480
ERAAREKIHE EKEQLALQLA ILLKENNDIE EGGSRQSLME MQCRHGARTS DSDQQTYLFQ 540
RGAEDRSWQH GQQPRSIPIH SCPKCGEVLP DIDTLQIHVM DCII 584 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI. GO:0005802; C:trans-Golgi network; ISS:UniProtKB. GO:0034613; P:cellular protein localization; IMP:MGI. GO:0090161; P:Golgi ribbon formation; ISS:UniProtKB. GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Compara. GO:0000042; P:protein targeting to Golgi; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |