CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014478
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Z-dependent protease inhibitor 
Protein Synonyms/Alias
 PZ-dependent protease inhibitor; PZI; Regeneration-associated serpin 1; RASP-1; Serpin A10 
Gene Name
 Serpina10 
Gene Synonyms/Alias
 Rasp1; Zpi 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
273NFASTFDKKFRCHILacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity). 
Sequence Annotation
 REGION 128 145 Heparin-binding (By similarity).
 CARBOHYD 23 23 N-linked (GlcNAc...) (Potential).
 CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
 CARBOHYD 69 69 N-linked (GlcNAc...) (Potential).
 CARBOHYD 172 172 N-linked (GlcNAc...) (Potential).
 CARBOHYD 189 189 N-linked (GlcNAc...) (Potential).
 CARBOHYD 287 287 N-linked (GlcNAc...) (Potential).  
Keyword
 Blood coagulation; Complete proteome; Glycoprotein; Hemostasis; Heparin-binding; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 436 AA 
Protein Sequence
MRVVSSLFLP VLLAEVWLVS SFNLSSHSPE APIRLVSQDY ENQTWEEYEW ADPRDDNEYW 60
LRASQQLSNE TSSFGFSLLR KISMRHDGNV IFSPFGLSVA MVNLMLGAKG ETKVQVENGL 120
NLQALSQAGP LILPALFKRV KETFSSNKKL GLTQGSFAFI HKDFEIKKTY FNLSTMYFDT 180
EYVPTNFRNS SQARGLMNHY INKETEGKIP KLFDEINPET KLILVDYILF KGKWLTPFDP 240
IFTEADTFHL DKYKAVKVPM MYREGNFAST FDKKFRCHIL KLPYQGNATM LVVLMEKSGD 300
HLALEDYLTT DLVEMWLQDM KTRKMEVFFP KFKLNQRYEM HELLKQVGIR RIFSTSADLS 360
ELSAVARNLQ VSKVVQQSVL EVDERGTEVV SGTVSEITAY CMPPVIKVDR PFHFIIYEEM 420
SQMLLFLGRV VNPTVL 436 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome.
 GO:0042246; P:tissue regeneration; IEP:RGD. 
Interpro
 IPR000295; Prot_inh_Lserp2.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 
Pfam
 PF00079; Serpin 
SMART
 SM00093; SERPIN 
PROSITE
 PS00284; SERPIN 
PRINTS
 PR00780; LEUSERPINII.