UniProt Accession

 USF2_HUMAN; Q15853; O00671; O00709; Q05750; Q07952; Q15851; Q15852; Q6FI33 

Genbank Protein ID

 X90824; X90825; X90826; Y07661; CR536504; AD000684; BC049821; S50537; M77476 

Genbank Nucleotide ID

 CAA62339.1; CAA62340.1; CAA62341.1; CAA68942.1; CAG38742.1; AAB51179.1; AAH49821.1; AAB24368.1 

Protein Name

 Upstream stimulatory factor 2 

Protein Synonyms/Alias

 Class B basic helix-loop-helix protein 12; bHLHb12; FOS-interacting protein; FIP; Major late transcription factor 2; Upstream transcription factor 2 

Gene Name

 USF2 

Gene Synonyms/Alias

 BHLHB12 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
224	RTHPYSPKIDGTRTP	ubiquitination	[1]
250	VERRRRDKINNWIVQ	ubiquitination	[2]
271	DCNADNSKTGASKGG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. 

Sequence Annotation

 DOMAIN 235 290 bHLH.
 REGION 307 328 Leucine-zipper.  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.
 GO:0043565; F:sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0019086; P:late viral mRNA transcription; IC:BHF-UCL.
 GO:0055088; P:lipid homeostasis; ISS:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0000432; P:positive regulation of transcription from RNA polymerase II promoter by glucose; IMP:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011598; bHLH_dom. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS